HCSGD entry for SETDB1
1. General information
| Official gene symbol | SETDB1 |
|---|---|
| Entrez ID | 9869 |
| Gene full name | SET domain, bifurcated 1 |
| Other gene symbols | ESET H3-K9-HMTase4 KG1T KMT1E TDRD21 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001833 | Inner cell mass cell proliferation | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IEA | molecular_function |
| GO:0060348 | Bone development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7957943163 | 0.1769647924 | 0.9999902473 | 0.8140847632 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1623055828 |
| GSE13712_SHEAR | Down | -0.4069240382 |
| GSE13712_STATIC | Down | -0.4175780780 |
| GSE19018 | Down | -0.0669417114 |
| GSE19899_A1 | Down | -0.0842476497 |
| GSE19899_A2 | Up | 0.1712362937 |
| PubMed_21979375_A1 | Up | 0.3386232413 |
| PubMed_21979375_A2 | Up | 0.6260048208 |
| GSE35957 | Down | -0.0778100143 |
| GSE36640 | Down | -0.4608481468 |
| GSE54402 | Down | -0.1148769778 |
| GSE9593 | Down | -0.2391884326 |
| GSE43922 | Down | -0.0099370002 |
| GSE24585 | Up | 0.1067367683 |
| GSE37065 | Down | -0.0583521025 |
| GSE28863_A1 | Up | 0.3381302092 |
| GSE28863_A2 | Up | 0.3140284993 |
| GSE28863_A3 | Down | -0.0792510130 |
| GSE28863_A4 | Down | -0.3654538260 |
| GSE48662 | Down | -0.0466054932 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-3p | MIMAT0004679 | MIRT038516 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT043011 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-152-3p | MIMAT0000438 | MIRT045818 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048947 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052718 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25512341 | Instead, lincRNA-p21 associates with the H3K9 methyltransferase SETDB1 and the maintenance DNA methyltransferase DNMT1, which is facilitated by the RNA-binding protein HNRNPK |
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