HCSGD entry for CDC20

1. General information

Official gene symbolCDC20
Entrez ID991
Gene full namecell division cycle 20
Other gene symbolsCDC20A bA276H19.3 p55CDC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0000922Spindle poleIEAcellular_component
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005680Anaphase-promoting complexIDAcellular_component
GO:0005813CentrosomeIEAcellular_component
GO:0005819SpindleTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0007049Cell cycleTASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0016567Protein ubiquitinationIEAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processIDA TASbiological_process
GO:0031915Positive regulation of synaptic plasticityISSbiological_process
GO:0040020Regulation of meiosisIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050773Regulation of dendrite developmentIEAbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051488Activation of anaphase-promoting complex activityIDAbiological_process
GO:0090129Positive regulation of synapse maturationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99864135860.00000646250.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-2.1813028681
GSE13712_SHEARDown-1.4437997246
GSE13712_STATICDown-0.6973362268
GSE19018Up0.0685527841
GSE19899_A1Down-3.2571624590
GSE19899_A2Down-4.5699186353
PubMed_21979375_A1Down-3.4811803692
PubMed_21979375_A2Down-6.4207909314
GSE35957Down-5.0376778306
GSE36640Down-4.7766478958
GSE54402Down-0.7627185146
GSE9593Down-3.0749739227
GSE43922Down-2.6115828939
GSE24585Down-0.2253704076
GSE37065Down-0.9496612931
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.5772738240

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016385MicroarrayFunctional MTI (Weak)20304954
hsa-miR-215-5pMIMAT0000272MIRT024643MicroarrayFunctional MTI (Weak)19074876
hsa-miR-34a-5pMIMAT0000255MIRT025414ProteomicsFunctional MTI (Weak)21566225
hsa-miR-34a-5pMIMAT0000255MIRT025414CLASHFunctional MTI (Weak)23622248
hsa-miR-192-5pMIMAT0000222MIRT026319MicroarrayFunctional MTI (Weak)19074876
hsa-miR-30a-5pMIMAT0000087MIRT028518ProteomicsFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT031615ProteomicsFunctional MTI (Weak)18668040
hsa-miR-941MIMAT0004984MIRT036567CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038870CLASHFunctional MTI (Weak)23622248
hsa-miR-188-5pMIMAT0000457MIRT044902CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046369CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049389CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050708CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17873905CDC20, a potential cancer therapeutic target, is negatively regulated by p53
17873905Here, we identified CDC20 that was frequently upregulated in many types of malignancies and remarkably suppressed by ectopic introduction of p53
17873905CDC20 expression was suppressed by genotoxic stresses in p53- and p21-dependent manners through CDE-CHR elements in the CDC20 promoter
17873905Furthermore, small interference RNA (siRNA)-mediated silencing of p53 induced CDC20 expression in normal human dermal fibroblast cells
17873905As we expected, treatment of cancer cells with siRNA against CDC20 induced G(2)/M arrest and suppressed cell growth
17873905Our results indicate that p53 inhibits tumor cell growth through the indirect regulation of CDC20 and that CDC20 might be a good potential therapeutic target for a broad spectrum of human cancer
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