HCSGD entry for MVP
1. General information
| Official gene symbol | MVP |
|---|---|
| Entrez ID | 9961 |
| Gene full name | major vault protein |
| Other gene symbols | LRP VAULT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005643 | Nuclear pore | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IDA | cellular_component |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0019903 | Protein phosphatase binding | IDA | molecular_function |
| GO:0023057 | Negative regulation of signaling | IDA | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0031953 | Negative regulation of protein autophosphorylation | IDA | biological_process |
| GO:0038127 | ERBB signaling pathway | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051028 | MRNA transport | IEA | biological_process |
| GO:0061099 | Negative regulation of protein tyrosine kinase activity | IDA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0072376 | Protein activation cascade | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0303048060 | 0.9332880818 | 0.4032622851 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5337721783 |
| GSE13712_SHEAR | Up | 0.0698766507 |
| GSE13712_STATIC | Up | 0.3464205171 |
| GSE19018 | Up | 0.2160597658 |
| GSE19899_A1 | Up | 0.0325035883 |
| GSE19899_A2 | Up | 0.2849495764 |
| PubMed_21979375_A1 | Up | 0.0710967908 |
| PubMed_21979375_A2 | Up | 0.7637503361 |
| GSE35957 | Down | -0.0571674937 |
| GSE36640 | Up | 0.5318299941 |
| GSE54402 | Down | -0.0283153620 |
| GSE9593 | Up | 0.6429004216 |
| GSE43922 | Down | -0.0169777765 |
| GSE24585 | Up | 0.6360901204 |
| GSE37065 | Down | -0.2045625829 |
| GSE28863_A1 | Up | 0.1918704150 |
| GSE28863_A2 | Up | 0.6199720421 |
| GSE28863_A3 | Down | -0.4258336946 |
| GSE28863_A4 | Up | 0.0187327865 |
| GSE48662 | Down | -0.1001071580 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022129 | Microarray | Functional MTI (Weak) | 18668037 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24997994 | Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation |
| 24997994 | Mass spectrometry analysis of the Bag3 Complex revealed a novel interaction between Bag3 and Major Vault Protein (MVP) |
| 24997994 | Mass spectrometry analysis of the Bag3 Complex revealed a novel interaction between Bag3 and Major Vault Protein (MVP) |
| 24997994 | Silencing of Bag3 or MVP shifts the cellular response to adriamycin to favor apoptosis |
| 24997994 | We demonstrate that Bag3 and MVP contribute to apoptosis resistance in therapy-induced senescence by increasing the level of activation of extracellular signal-regulated kinase1/2 (ERK1/2) |
| 24997994 | Silencing of either Bag3 or MVP decreased ERK1/2 activation and promoted apoptosis in adriamycin-treated cells |
| 24997994 | An increase in nuclear accumulation of MVP is observed during therapy-induced senescence and the shift in MVP subcellular localization is Bag3-dependent |
| 24997994 | We propose a model in which Bag3 binds to MVP and facilitates MVP accumulation in the nucleus, which sustains ERK1/2 activation |
| 24997994 | We propose a model in which Bag3 binds to MVP and facilitates MVP accumulation in the nucleus, which sustains ERK1/2 activation |
| 24997994 | We confirmed that silencing of Bag3 or MVP shifts the response toward apoptosis and regulates ERK1/2 activation in a panel of diverse breast cancer cell lines |
Entries Per Page
Displaying Page of
