HCSGD entry for NR1I3

1. General information

Official gene symbolNR1I3
Entrez ID9970
Gene full namenuclear receptor subfamily 1, group I, member 3
Other gene symbolsCAR CAR1 MB67
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEA TASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA TASmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityTASmolecular_function
GO:0004882Androgen receptor activityTASmolecular_function
GO:0004887Thyroid hormone receptor activityIEAmolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolIEAcellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0030521Androgen receptor signaling pathwayTASbiological_process
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51905303750.93690148170.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0680910506
GSE13712_SHEARUp0.0056716945
GSE13712_STATICDown-0.0079888794
GSE19018Down-0.0314165200
GSE19899_A1Up0.1607746406
GSE19899_A2Up0.0932696584
PubMed_21979375_A1Up0.2318135985
PubMed_21979375_A2Up0.0818663377
GSE35957Up0.1906076160
GSE36640Up0.0050922883
GSE54402Up0.1239629158
GSE9593Up0.1733893270
GSE43922Up0.0125365483
GSE24585Up0.0067423506
GSE37065Down-0.0248812517
GSE28863_A1Down-0.0974651993
GSE28863_A2Up0.2114382936
GSE28863_A3Up0.1605437584
GSE28863_A4Down-0.0523158191
GSE48662Down-0.0344631201

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DehydroepiandrosteroneDB01708 EXPT00519 | DB06593
16,17-Androstene-3-OlDB01889 EXPT00580
(5BETA)-PREGNANE-3,20-DIONEDB07557 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.