HCSGD entry for NR1D2

1. General information

Official gene symbolNR1D2
Entrez ID9975
Gene full namenuclear receptor subfamily 1, group D, member 2
Other gene symbolsBD73 EAR-1R RVR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001046Core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEA TAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0019216Regulation of lipid metabolic processISSbiological_process
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0042752Regulation of circadian rhythmISSbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0048511Rhythmic processIEAbiological_process
GO:0050727Regulation of inflammatory responseISSbiological_process
GO:0055088Lipid homeostasisISSbiological_process
GO:2000505Regulation of energy homeostasisISSbiological_process
GO:2001014Regulation of skeletal muscle cell differentiationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28636882340.01817433230.98572578790.2637081588

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3129885674
GSE13712_SHEARUp0.5405829345
GSE13712_STATICUp0.3840516722
GSE19018Up0.8249375333
GSE19899_A1Down-1.3094416744
GSE19899_A2Down-1.5314680421
PubMed_21979375_A1Down-1.0526395716
PubMed_21979375_A2Down-1.0596394024
GSE35957Down-0.0483462175
GSE36640Up0.1979851096
GSE54402Down-0.6250670494
GSE9593Up0.6738360958
GSE43922Down-1.2094629710
GSE24585Up0.1131181651
GSE37065Up0.2819433956
GSE28863_A1Up0.1886452972
GSE28863_A2Up0.1689520019
GSE28863_A3Down-0.0153209743
GSE28863_A4Down-0.3143919929
GSE48662Down-0.1347693712

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT021292SequencingFunctional MTI (Weak)20371350
hsa-miR-132-3pMIMAT0000426MIRT021733MicroarrayFunctional MTI (Weak)17612493
hsa-miR-10a-5pMIMAT0000253MIRT025595SequencingFunctional MTI (Weak)20371350
hsa-miR-744-5pMIMAT0004945MIRT037578CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.