HCSGD entry for CASP8AP2
1. General information
| Official gene symbol | CASP8AP2 |
|---|---|
| Entrez ID | 9994 |
| Gene full name | caspase 8 associated protein 2 |
| Other gene symbols | CED-4 FLASH RIP25 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IDA | molecular_function |
| GO:0005123 | Death receptor binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IMP ISS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008625 | Extrinsic apoptotic signaling pathway via death domain receptors | IMP ISS | biological_process |
| GO:0008656 | Cysteine-type endopeptidase activator activity involved in apoptotic process | ISS | molecular_function |
| GO:0016505 | Peptidase activator activity involved in apoptotic process | ISS | molecular_function |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0032184 | SUMO polymer binding | IDA | molecular_function |
| GO:0036337 | Fas signaling pathway | IMP | biological_process |
| GO:0071260 | Cellular response to mechanical stimulus | IEP | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9807762623 | 0.0226520497 | 0.9999902473 | 0.2897859086 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0252894704 |
| GSE13712_SHEAR | Up | 0.0707951234 |
| GSE13712_STATIC | Down | -0.2125688733 |
| GSE19018 | Down | -0.0866955694 |
| GSE19899_A1 | Down | -0.4312378934 |
| GSE19899_A2 | Down | -0.7791774899 |
| PubMed_21979375_A1 | Down | -0.2975154707 |
| PubMed_21979375_A2 | Down | -1.3139647065 |
| GSE35957 | Down | -0.4316942027 |
| GSE36640 | Down | -0.6730978616 |
| GSE54402 | Down | -0.2022385812 |
| GSE9593 | Down | -0.2792812743 |
| GSE43922 | Down | -0.6208567581 |
| GSE24585 | Up | 0.1316409732 |
| GSE37065 | Up | 0.1349468679 |
| GSE28863_A1 | Up | 0.0353479571 |
| GSE28863_A2 | Up | 0.5095088138 |
| GSE28863_A3 | Down | -0.2989973214 |
| GSE28863_A4 | Down | -0.0502561098 |
| GSE48662 | Down | -0.6742097193 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT006519 | Luciferase reporter assay | Functional MTI | 19721136 |
| hsa-miR-598-3p | MIMAT0003266 | MIRT040491 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-330-3p | MIMAT0000751 | MIRT043844 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26208142 | We identified caspase-8-binding protein FLICE-associated huge protein (FLASH) as a novel E2A-binding partner by using a yeast two-hybrid screening |
Entries Per Page
Displaying Page of
