HCSGD entry for AASS

1. General information

Official gene symbolAASS
Entrez ID10157
Gene full nameaminoadipate-semialdehyde synthase
Other gene symbolsLKR/SDH LKRSDH LORSDH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDA TAScellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006554Lysine catabolic processNAS TASbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopineIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047130Saccharopine dehydrogenase (NADP+, L-lysine-forming) activityEXPmolecular_function
GO:0047131Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activityEXP NASmolecular_function
GO:0051262Protein tetramerizationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99631220700.00052554610.99999024730.0423024465

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1238158676
GSE13712_SHEARDown-0.6603094276
GSE13712_STATICDown-0.3755563299
GSE19018Down-0.5556169105
GSE19899_A1Down-0.6009185663
GSE19899_A2Down-1.7479334770
PubMed_21979375_A1Down-1.8613611448
PubMed_21979375_A2Down-1.7921769051
GSE35957Down-0.5458514146
GSE36640Down-0.9680695147
GSE54402Down-0.2561829826
GSE9593Down-0.9768041673
GSE43922Down-1.4633708596
GSE24585Up0.6476726513
GSE37065Down-0.2060576553
GSE28863_A1Up0.1729270943
GSE28863_A2Down-0.6616256266
GSE28863_A3Down-0.2630087047
GSE28863_A4Down-0.3304103302
GSE48662Down-0.3926004248

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
Nadph Dihydro-Nicotinamide-Adenine-DinucleotidephosphateDB02338 EXPT02321
N-(5-Amino-5-Carboxypentyl)Glutamic AcidDB04207 EXPT02906

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.