HCSGD entry for AASS

1. General information

Official gene symbolAASS
Entrez ID10157
Gene full nameaminoadipate-semialdehyde synthase
Other gene symbolsLKR/SDH LKRSDH LORSDH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDA TAScellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006554Lysine catabolic processNAS TASbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopineIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047130Saccharopine dehydrogenase (NADP+, L-lysine-forming) activityEXPmolecular_function
GO:0047131Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activityEXP NASmolecular_function
GO:0051262Protein tetramerizationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99631220700.00052554610.99999024730.0423024465

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1238158676
GSE13712_SHEARDown-0.6603094276
GSE13712_STATICDown-0.3755563299
GSE19018Down-0.5556169105
GSE19899_A1Down-0.6009185663
GSE19899_A2Down-1.7479334770
PubMed_21979375_A1Down-1.8613611448
PubMed_21979375_A2Down-1.7921769051
GSE35957Down-0.5458514146
GSE36640Down-0.9680695147
GSE54402Down-0.2561829826
GSE9593Down-0.9768041673
GSE43922Down-1.4633708596
GSE24585Up0.6476726513
GSE37065Down-0.2060576553
GSE28863_A1Up0.1729270943
GSE28863_A2Down-0.6616256266
GSE28863_A3Down-0.2630087047
GSE28863_A4Down-0.3304103302
GSE48662Down-0.3926004248

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
Nadph Dihydro-Nicotinamide-Adenine-DinucleotidephosphateDB02338 EXPT02321
N-(5-Amino-5-Carboxypentyl)Glutamic AcidDB04207 EXPT02906

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.