HCSGD entry for NOD1

1. General information

Official gene symbol	NOD1
Entrez ID	10392
Gene full name	nucleotide-binding oligomerization domain containing 1
Other gene symbols	CARD4 CLR7.1 NLRC1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000187	Activation of MAPK activity	TAS	biological_process
GO:0002224	Toll-like receptor signaling pathway	TAS	biological_process
GO:0002606	Positive regulation of dendritic cell antigen processing and presentation	IEA ISS	biological_process
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	biological_process
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	biological_process
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005622	Intracellular	IEA	cellular_component
GO:0005737	Cytoplasm	IDA TAS	cellular_component
GO:0005829	Cytosol	TAS	cellular_component
GO:0006915	Apoptotic process	TAS	biological_process
GO:0006919	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological_process
GO:0006952	Defense response	TAS	biological_process
GO:0006954	Inflammatory response	TAS	biological_process
GO:0007165	Signal transduction	TAS	biological_process
GO:0007254	JNK cascade	TAS	biological_process
GO:0008656	Cysteine-type endopeptidase activator activity involved in apoptotic process	TAS	molecular_function
GO:0009595	Detection of biotic stimulus	TAS	biological_process
GO:0016045	Detection of bacterium	IDA	biological_process
GO:0016323	Basolateral plasma membrane	IDA	cellular_component
GO:0016324	Apical plasma membrane	IEA	cellular_component
GO:0032755	Positive regulation of interleukin-6 production	IEA	biological_process
GO:0032760	Positive regulation of tumor necrosis factor production	IEA	biological_process
GO:0034134	Toll-like receptor 2 signaling pathway	TAS	biological_process
GO:0034138	Toll-like receptor 3 signaling pathway	TAS	biological_process
GO:0034142	Toll-like receptor 4 signaling pathway	TAS	biological_process
GO:0034146	Toll-like receptor 5 signaling pathway	TAS	biological_process
GO:0034162	Toll-like receptor 9 signaling pathway	TAS	biological_process
GO:0034166	Toll-like receptor 10 signaling pathway	TAS	biological_process
GO:0035556	Intracellular signal transduction	IDA	biological_process
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TAS	biological_process
GO:0035872	Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	TAS	biological_process
GO:0038123	Toll-like receptor TLR1:TLR2 signaling pathway	TAS	biological_process
GO:0038124	Toll-like receptor TLR6:TLR2 signaling pathway	TAS	biological_process
GO:0042228	Interleukin-8 biosynthetic process	IDA	biological_process
GO:0042742	Defense response to bacterium	IDA	biological_process
GO:0042802	Identical protein binding	IDA IPI	molecular_function
GO:0042803	Protein homodimerization activity	IPI	molecular_function
GO:0042834	Peptidoglycan binding	TAS	molecular_function
GO:0042981	Regulation of apoptotic process	IEA	biological_process
GO:0043123	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA IEA	biological_process
GO:0043280	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	biological_process
GO:0045087	Innate immune response	TAS	biological_process
GO:0046330	Positive regulation of JNK cascade	IEA	biological_process
GO:0050700	CARD domain binding	IDA	molecular_function
GO:0050830	Defense response to Gram-positive bacterium	IEA	biological_process
GO:0051092	Positive regulation of NF-kappaB transcription factor activity	IDA TAS	biological_process
GO:0051259	Protein oligomerization	TAS	biological_process
GO:0051403	Stress-activated MAPK cascade	TAS	biological_process
GO:0070374	Positive regulation of ERK1 and ERK2 cascade	IEA	biological_process
GO:0070423	Nucleotide-binding oligomerization domain containing signaling pathway	TAS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.9194701417	0.0776277345	0.9999902473	0.5275319659

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1183431145
GSE13712_SHEAR	Down	-0.6969732381
GSE13712_STATIC	Down	-0.5925909991
GSE19018	Up	0.0882174421
GSE19899_A1	Up	0.0980379107
GSE19899_A2	Down	-0.2611625188
PubMed_21979375_A1	Down	-0.4389052688
PubMed_21979375_A2	Down	-0.2004036027
GSE35957	Down	-0.4632813837
GSE36640	Down	-0.6017215678
GSE54402	Down	-0.1361390774
GSE9593	Down	-0.0632459747
GSE43922	Up	0.0239569071
GSE24585	Up	0.2321789945
GSE37065	Down	-0.2447816090
GSE28863_A1	Up	0.4692192542
GSE28863_A2	Up	0.3651501417
GSE28863_A3	Down	-0.0551911863
GSE28863_A4	Down	-0.1148868872
GSE48662	Down	-0.1330502433

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results