HCSGD entry for NOD1

1. General information

Official gene symbolNOD1
Entrez ID10392
Gene full namenucleotide-binding oligomerization domain containing 1
Other gene symbolsCARD4 CLR7.1 NLRC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002606Positive regulation of dendritic cell antigen processing and presentationIEA ISSbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0006952Defense responseTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processTASmolecular_function
GO:0009595Detection of biotic stimulusTASbiological_process
GO:0016045Detection of bacteriumIDAbiological_process
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042228Interleukin-8 biosynthetic processIDAbiological_process
GO:0042742Defense response to bacteriumIDAbiological_process
GO:0042802Identical protein bindingIDA IPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0042834Peptidoglycan bindingTASmolecular_function
GO:0042981Regulation of apoptotic processIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDA IEAbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046330Positive regulation of JNK cascadeIEAbiological_process
GO:0050700CARD domain bindingIDAmolecular_function
GO:0050830Defense response to Gram-positive bacteriumIEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDA TASbiological_process
GO:0051259Protein oligomerizationTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91947014170.07762773450.99999024730.5275319659

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1183431145
GSE13712_SHEARDown-0.6969732381
GSE13712_STATICDown-0.5925909991
GSE19018Up0.0882174421
GSE19899_A1Up0.0980379107
GSE19899_A2Down-0.2611625188
PubMed_21979375_A1Down-0.4389052688
PubMed_21979375_A2Down-0.2004036027
GSE35957Down-0.4632813837
GSE36640Down-0.6017215678
GSE54402Down-0.1361390774
GSE9593Down-0.0632459747
GSE43922Up0.0239569071
GSE24585Up0.2321789945
GSE37065Down-0.2447816090
GSE28863_A1Up0.4692192542
GSE28863_A2Up0.3651501417
GSE28863_A3Down-0.0551911863
GSE28863_A4Down-0.1148868872
GSE48662Down-0.1330502433

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.