HCSGD entry for MGLL
1. General information
| Official gene symbol | MGLL |
|---|---|
| Entrez ID | 11343 |
| Gene full name | monoglyceride lipase |
| Other gene symbols | HU-K5 HUK5 MAGL MGL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004622 | Lysophospholipase activity | TAS | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006629 | Lipid metabolic process | TAS | biological_process |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008289 | Lipid binding | IEA | molecular_function |
| GO:0009966 | Regulation of signal transduction | ISS | biological_process |
| GO:0019369 | Arachidonic acid metabolic process | IEA ISS | biological_process |
| GO:0019433 | Triglyceride catabolic process | IEA TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0036155 | Acylglycerol acyl-chain remodeling | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0046464 | Acylglycerol catabolic process | IEA ISS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0047372 | Acylglycerol lipase activity | IEA ISS TAS | molecular_function |
| GO:0050727 | Regulation of inflammatory response | IEA ISS | biological_process |
| GO:0051930 | Regulation of sensory perception of pain | IEA ISS | biological_process |
| GO:0060292 | Long term synaptic depression | IEA | biological_process |
| GO:2000124 | Regulation of endocannabinoid signaling pathway | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0157893127 | 0.6543920938 | 0.3109908003 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1867873728 |
| GSE13712_SHEAR | Up | 1.1895500650 |
| GSE13712_STATIC | Up | 0.8086027300 |
| GSE19018 | Up | 0.6637800133 |
| GSE19899_A1 | Down | -0.2604408260 |
| GSE19899_A2 | Down | -0.4573737982 |
| PubMed_21979375_A1 | Up | 0.4089893605 |
| PubMed_21979375_A2 | Down | -0.2268770194 |
| GSE35957 | Up | 0.5781369434 |
| GSE36640 | Up | 1.0692487768 |
| GSE54402 | Down | -0.4550883033 |
| GSE9593 | Up | 2.0739510546 |
| GSE43922 | Down | -0.1401990251 |
| GSE24585 | Down | -0.0597670159 |
| GSE37065 | Up | 0.5446319720 |
| GSE28863_A1 | Down | -0.0323453671 |
| GSE28863_A2 | Up | 0.2615177340 |
| GSE28863_A3 | Down | -0.0943932801 |
| GSE28863_A4 | Down | -0.0787853360 |
| GSE48662 | Down | -0.0052651718 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025844 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047880 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22178194 | Affymetrix gene array data showed NeuT-induced alterations in the transcription of many enzymes involved in lipid metabolism, several of which (ACSL3, CHPT1, PLD1, LIPG, MGLL, LDL and NPC1) could be confirmed by quantitative realtime PCR |
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