HCSGD entry for MGLL

1. General information

Official gene symbolMGLL
Entrez ID11343
Gene full namemonoglyceride lipase
Other gene symbolsHU-K5 HUK5 MAGL MGL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004622Lysophospholipase activityTASmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006629Lipid metabolic processTASbiological_process
GO:0006633Fatty acid biosynthetic processIEAbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008289Lipid bindingIEAmolecular_function
GO:0009966Regulation of signal transductionISSbiological_process
GO:0019369Arachidonic acid metabolic processIEA ISSbiological_process
GO:0019433Triglyceride catabolic processIEA TASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0036155Acylglycerol acyl-chain remodelingTASbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045202SynapseIEAcellular_component
GO:0046464Acylglycerol catabolic processIEA ISSbiological_process
GO:0046474Glycerophospholipid biosynthetic processTASbiological_process
GO:0047372Acylglycerol lipase activityIEA ISS TASmolecular_function
GO:0050727Regulation of inflammatory responseIEA ISSbiological_process
GO:0051930Regulation of sensory perception of painIEA ISSbiological_process
GO:0060292Long term synaptic depressionIEAbiological_process
GO:2000124Regulation of endocannabinoid signaling pathwayIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01578931270.65439209380.31099080031.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1867873728
GSE13712_SHEARUp1.1895500650
GSE13712_STATICUp0.8086027300
GSE19018Up0.6637800133
GSE19899_A1Down-0.2604408260
GSE19899_A2Down-0.4573737982
PubMed_21979375_A1Up0.4089893605
PubMed_21979375_A2Down-0.2268770194
GSE35957Up0.5781369434
GSE36640Up1.0692487768
GSE54402Down-0.4550883033
GSE9593Up2.0739510546
GSE43922Down-0.1401990251
GSE24585Down-0.0597670159
GSE37065Up0.5446319720
GSE28863_A1Down-0.0323453671
GSE28863_A2Up0.2615177340
GSE28863_A3Down-0.0943932801
GSE28863_A4Down-0.0787853360
GSE48662Down-0.0052651718

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT025844MicroarrayFunctional MTI (Weak)19073608
hsa-miR-30c-5pMIMAT0000244MIRT047880CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22178194Affymetrix gene array data showed NeuT-induced alterations in the transcription of many enzymes involved in lipid metabolism, several of which (ACSL3, CHPT1, PLD1, LIPG, MGLL, LDL and NPC1) could be confirmed by quantitative realtime PCR
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