HCSGD entry for RASGRP4

1. General information

Official gene symbolRASGRP4
Entrez ID115727
Gene full nameRAS guanyl releasing protein 4
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005088Ras guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayNASbiological_process
GO:0007202Activation of phospholipase C activityNASbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayNASbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0009991Response to extracellular stimulusIDAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016049Cell growthIDAbiological_process
GO:0019992Diacylglycerol bindingTASmolecular_function
GO:0030099Myeloid cell differentiationTASbiological_process
GO:0030742GTP-dependent protein bindingNASmolecular_function
GO:0032318Regulation of Ras GTPase activityIDAbiological_process
GO:0043087Regulation of GTPase activityIDAbiological_process
GO:0046579Positive regulation of Ras protein signal transductionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41660694120.91997726910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1719566580
GSE13712_SHEARDown-0.0669975436
GSE13712_STATICUp0.1754255342
GSE19018Up0.1132252968
GSE19899_A1Up0.1030075205
GSE19899_A2Up0.0430226610
PubMed_21979375_A1Down-0.2341876119
PubMed_21979375_A2Up0.1205392132
GSE35957Up0.1929050693
GSE36640Down-0.0671783326
GSE54402Up0.1140239427
GSE9593Down-0.0063997585
GSE43922Up0.1106750942
GSE24585Up0.3513483296
GSE37065Down-0.0021535989
GSE28863_A1Up0.0342341803
GSE28863_A2Up0.0100163263
GSE28863_A3Up0.0801245567
GSE28863_A4Up0.0477785620
GSE48662Up0.2277719837

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.