HCSGD entry for RASGRP4

1. General information

Official gene symbolRASGRP4
Entrez ID115727
Gene full nameRAS guanyl releasing protein 4
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005088Ras guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayNASbiological_process
GO:0007202Activation of phospholipase C activityNASbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayNASbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0009991Response to extracellular stimulusIDAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016049Cell growthIDAbiological_process
GO:0019992Diacylglycerol bindingTASmolecular_function
GO:0030099Myeloid cell differentiationTASbiological_process
GO:0030742GTP-dependent protein bindingNASmolecular_function
GO:0032318Regulation of Ras GTPase activityIDAbiological_process
GO:0043087Regulation of GTPase activityIDAbiological_process
GO:0046579Positive regulation of Ras protein signal transductionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41660694120.91997726910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1719566580
GSE13712_SHEARDown-0.0669975436
GSE13712_STATICUp0.1754255342
GSE19018Up0.1132252968
GSE19899_A1Up0.1030075205
GSE19899_A2Up0.0430226610
PubMed_21979375_A1Down-0.2341876119
PubMed_21979375_A2Up0.1205392132
GSE35957Up0.1929050693
GSE36640Down-0.0671783326
GSE54402Up0.1140239427
GSE9593Down-0.0063997585
GSE43922Up0.1106750942
GSE24585Up0.3513483296
GSE37065Down-0.0021535989
GSE28863_A1Up0.0342341803
GSE28863_A2Up0.0100163263
GSE28863_A3Up0.0801245567
GSE28863_A4Up0.0477785620
GSE48662Up0.2277719837

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.