HCSGD entry for NLGN1

1. General information

Official gene symbol	NLGN1
Entrez ID	22871
Gene full name	neuroligin 1
Other gene symbols	NL1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0002087	Regulation of respiratory gaseous exchange by neurological system process	IEA	biological_process
GO:0004872	Receptor activity	IBA ISS	molecular_function
GO:0005887	Integral component of plasma membrane	IBA ISS	cellular_component
GO:0006605	Protein targeting	ISS	biological_process
GO:0007157	Heterophilic cell-cell adhesion	ISS	biological_process
GO:0007158	Neuron cell-cell adhesion	ISS TAS	biological_process
GO:0007399	Nervous system development	ISS	biological_process
GO:0007416	Synapse assembly	IBA ISS	biological_process
GO:0009897	External side of plasma membrane	IEA	cellular_component
GO:0009986	Cell surface	IBA ISS	cellular_component
GO:0016080	Synaptic vesicle targeting	ISS	biological_process
GO:0016339	Calcium-dependent cell-cell adhesion	ISS	biological_process
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	IEA	cellular_component
GO:0023041	Neuronal signal transduction	TAS	biological_process
GO:0030054	Cell junction	IEA	cellular_component
GO:0030425	Dendrite	ISS	cellular_component
GO:0032230	Positive regulation of synaptic transmission, GABAergic	ISS	biological_process
GO:0032433	Filopodium tip	ISS	cellular_component
GO:0035418	Protein localization to synapse	ISS	biological_process
GO:0042043	Neurexin family protein binding	IBA ISS	molecular_function
GO:0045184	Establishment of protein localization	ISS	biological_process
GO:0045202	Synapse	IBA ISS	cellular_component
GO:0045211	Postsynaptic membrane	IEA	cellular_component
GO:0045664	Regulation of neuron differentiation	ISS	biological_process
GO:0046983	Protein dimerization activity	ISS	molecular_function
GO:0048789	Cytoskeletal matrix organization at active zone	ISS	biological_process
GO:0050839	Cell adhesion molecule binding	ISS	molecular_function
GO:0051260	Protein homooligomerization	ISS	biological_process
GO:0051290	Protein heterotetramerization	IEA	biological_process
GO:0051491	Positive regulation of filopodium assembly	ISS	biological_process
GO:0051965	Positive regulation of synapse assembly	ISS	biological_process
GO:0051968	Positive regulation of synaptic transmission, glutamatergic	ISS	biological_process
GO:0060999	Positive regulation of dendritic spine development	ISS	biological_process
GO:0072553	Terminal button organization	ISS	biological_process
GO:0097091	Synaptic vesicle clustering	ISS	biological_process
GO:0097104	Postsynaptic membrane assembly	ISS	biological_process
GO:0097105	Presynaptic membrane assembly	ISS	biological_process
GO:0097113	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering	ISS	biological_process
GO:0097114	N-methyl-D-aspartate receptor clustering	ISS	biological_process
GO:0097115	Neurexin clustering	ISS	biological_process
GO:0097119	Postsynaptic density protein 95 clustering	ISS	biological_process
GO:0097120	Receptor localization to synapse	ISS	biological_process
GO:0097481	Neuronal postsynaptic density	TAS	cellular_component
GO:1900029	Positive regulation of ruffle assembly	ISS	biological_process
GO:1900244	Positive regulation of synaptic vesicle endocytosis	ISS	biological_process
GO:1902533	Positive regulation of intracellular signal transduction	ISS	biological_process
GO:2000302	Positive regulation of synaptic vesicle exocytosis	ISS	biological_process
GO:2000310	Regulation of N-methyl-D-aspartate selective glutamate receptor activity	ISS	biological_process
GO:2000311	Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	ISS	biological_process
GO:2000463	Positive regulation of excitatory postsynaptic membrane potential	ISS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.8627567646	0.0008835910	0.9999902473	0.0566338902

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.3393604522
GSE13712_SHEAR	Up	1.2531210862
GSE13712_STATIC	Up	1.2170910014
GSE19018	Down	-0.7746571076
GSE19899_A1	Down	-0.1068892751
GSE19899_A2	Down	-2.5181196655
PubMed_21979375_A1	Down	-0.3857073358
PubMed_21979375_A2	Down	-1.2551630486
GSE35957	Down	-0.5171672186
GSE36640	Down	-0.7990141410
GSE54402	Down	-0.9996369060
GSE9593	Down	-0.4082159299
GSE43922	Down	-1.0155823716
GSE24585	Down	-0.2017363241
GSE37065	Down	-0.5677874494
GSE28863_A1	Down	-0.1698146653
GSE28863_A2	Down	-0.7403814889
GSE28863_A3	Down	-0.7300749892
GSE28863_A4	Up	0.0725049722
GSE48662	Down	-0.6698867955

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results