HCSGD entry for NLGN1

1. General information

Official gene symbolNLGN1
Entrez ID22871
Gene full nameneuroligin 1
Other gene symbolsNL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002087Regulation of respiratory gaseous exchange by neurological system processIEAbiological_process
GO:0004872Receptor activityIBA ISSmolecular_function
GO:0005887Integral component of plasma membraneIBA ISScellular_component
GO:0006605Protein targetingISSbiological_process
GO:0007157Heterophilic cell-cell adhesionISSbiological_process
GO:0007158Neuron cell-cell adhesionISS TASbiological_process
GO:0007399Nervous system developmentISSbiological_process
GO:0007416Synapse assemblyIBA ISSbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIBA ISScellular_component
GO:0016080Synaptic vesicle targetingISSbiological_process
GO:0016339Calcium-dependent cell-cell adhesionISSbiological_process
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIEAcellular_component
GO:0023041Neuronal signal transductionTASbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteISScellular_component
GO:0032230Positive regulation of synaptic transmission, GABAergicISSbiological_process
GO:0032433Filopodium tipISScellular_component
GO:0035418Protein localization to synapseISSbiological_process
GO:0042043Neurexin family protein bindingIBA ISSmolecular_function
GO:0045184Establishment of protein localizationISSbiological_process
GO:0045202SynapseIBA ISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045664Regulation of neuron differentiationISSbiological_process
GO:0046983Protein dimerization activityISSmolecular_function
GO:0048789Cytoskeletal matrix organization at active zoneISSbiological_process
GO:0050839Cell adhesion molecule bindingISSmolecular_function
GO:0051260Protein homooligomerizationISSbiological_process
GO:0051290Protein heterotetramerizationIEAbiological_process
GO:0051491Positive regulation of filopodium assemblyISSbiological_process
GO:0051965Positive regulation of synapse assemblyISSbiological_process
GO:0051968Positive regulation of synaptic transmission, glutamatergicISSbiological_process
GO:0060999Positive regulation of dendritic spine developmentISSbiological_process
GO:0072553Terminal button organizationISSbiological_process
GO:0097091Synaptic vesicle clusteringISSbiological_process
GO:0097104Postsynaptic membrane assemblyISSbiological_process
GO:0097105Presynaptic membrane assemblyISSbiological_process
GO:0097113Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringISSbiological_process
GO:0097114N-methyl-D-aspartate receptor clusteringISSbiological_process
GO:0097115Neurexin clusteringISSbiological_process
GO:0097119Postsynaptic density protein 95 clusteringISSbiological_process
GO:0097120Receptor localization to synapseISSbiological_process
GO:0097481Neuronal postsynaptic densityTAScellular_component
GO:1900029Positive regulation of ruffle assemblyISSbiological_process
GO:1900244Positive regulation of synaptic vesicle endocytosisISSbiological_process
GO:1902533Positive regulation of intracellular signal transductionISSbiological_process
GO:2000302Positive regulation of synaptic vesicle exocytosisISSbiological_process
GO:2000310Regulation of N-methyl-D-aspartate selective glutamate receptor activityISSbiological_process
GO:2000311Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISSbiological_process
GO:2000463Positive regulation of excitatory postsynaptic membrane potentialISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86275676460.00088359100.99999024730.0566338902

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3393604522
GSE13712_SHEARUp1.2531210862
GSE13712_STATICUp1.2170910014
GSE19018Down-0.7746571076
GSE19899_A1Down-0.1068892751
GSE19899_A2Down-2.5181196655
PubMed_21979375_A1Down-0.3857073358
PubMed_21979375_A2Down-1.2551630486
GSE35957Down-0.5171672186
GSE36640Down-0.7990141410
GSE54402Down-0.9996369060
GSE9593Down-0.4082159299
GSE43922Down-1.0155823716
GSE24585Down-0.2017363241
GSE37065Down-0.5677874494
GSE28863_A1Down-0.1698146653
GSE28863_A2Down-0.7403814889
GSE28863_A3Down-0.7300749892
GSE28863_A4Up0.0725049722
GSE48662Down-0.6698867955

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.