HCSGD entry for HEY1

1. General information

Official gene symbolHEY1
Entrez ID23462
Gene full namehairy/enhancer-of-split related with YRPW motif 1
Other gene symbolsBHLHb31 CHF2 HERP2 HESR1 HRT-1 OAF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0000988Protein binding transcription factor activityIDAmolecular_function
GO:0001525AngiogenesisIEPbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0003184Pulmonary valve morphogenesisISSbiological_process
GO:0003190Atrioventricular valve formationISSbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationISSbiological_process
GO:0003199Endocardial cushion to mesenchymal transition involved in heart valve formationIEAbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003208Cardiac ventricle morphogenesisISSbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmISScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007219Notch signaling pathwayIDA TASbiological_process
GO:0008134Transcription factor bindingNASmolecular_function
GO:0009948Anterior/posterior axis specificationIEAbiological_process
GO:0035912Dorsal aorta morphogenesisISSbiological_process
GO:0035939Microsatellite bindingIDAmolecular_function
GO:0036304Umbilical cord morphogenesisISSbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045746Negative regulation of Notch signaling pathwayIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0060317Cardiac epithelial to mesenchymal transitionISSbiological_process
GO:0060347Heart trabecula formationISSbiological_process
GO:0060411Cardiac septum morphogenesisISSbiological_process
GO:0060412Ventricular septum morphogenesisISSbiological_process
GO:0060716Labyrinthine layer blood vessel developmentISSbiological_process
GO:0060842Arterial endothelial cell differentiationISSbiological_process
GO:0061314Notch signaling involved in heart developmentICbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIEAbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIDAbiological_process
GO:2000820Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationIDAbiological_process
GO:2001212Regulation of vasculogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00054163600.12401307700.06600185190.6771825970

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1831784378
GSE13712_SHEARDown-2.0697048009
GSE13712_STATICDown-0.9254573948
GSE19018Down-0.1844259316
GSE19899_A1Up1.9534359556
GSE19899_A2Up2.0934581353
PubMed_21979375_A1Up3.5735432205
PubMed_21979375_A2Up3.9654803076
GSE35957Up0.1616285015
GSE36640Up0.8045987650
GSE54402Up3.3419460003
GSE9593Up0.3840748414
GSE43922Up1.7734522230
GSE24585Down-1.9194677758
GSE37065Down-0.0109110323
GSE28863_A1Down-0.2805962756
GSE28863_A2Down-0.1485229704
GSE28863_A3Up0.4452369738
GSE28863_A4Up0.1863822500
GSE48662Up0.1258796995

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017049MicroarrayFunctional MTI (Weak)18185580
hsa-miR-375MIMAT0000728MIRT019763MicroarrayFunctional MTI (Weak)20215506
hsa-miR-30b-5pMIMAT0000420MIRT046126CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.