HCSGD entry for HEY1

1. General information

Official gene symbolHEY1
Entrez ID23462
Gene full namehairy/enhancer-of-split related with YRPW motif 1
Other gene symbolsBHLHb31 CHF2 HERP2 HESR1 HRT-1 OAF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0000988Protein binding transcription factor activityIDAmolecular_function
GO:0001525AngiogenesisIEPbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0003184Pulmonary valve morphogenesisISSbiological_process
GO:0003190Atrioventricular valve formationISSbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationISSbiological_process
GO:0003199Endocardial cushion to mesenchymal transition involved in heart valve formationIEAbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003208Cardiac ventricle morphogenesisISSbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmISScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007219Notch signaling pathwayIDA TASbiological_process
GO:0008134Transcription factor bindingNASmolecular_function
GO:0009948Anterior/posterior axis specificationIEAbiological_process
GO:0035912Dorsal aorta morphogenesisISSbiological_process
GO:0035939Microsatellite bindingIDAmolecular_function
GO:0036304Umbilical cord morphogenesisISSbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045746Negative regulation of Notch signaling pathwayIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0060317Cardiac epithelial to mesenchymal transitionISSbiological_process
GO:0060347Heart trabecula formationISSbiological_process
GO:0060411Cardiac septum morphogenesisISSbiological_process
GO:0060412Ventricular septum morphogenesisISSbiological_process
GO:0060716Labyrinthine layer blood vessel developmentISSbiological_process
GO:0060842Arterial endothelial cell differentiationISSbiological_process
GO:0061314Notch signaling involved in heart developmentICbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIEAbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIDAbiological_process
GO:2000820Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationIDAbiological_process
GO:2001212Regulation of vasculogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00054163600.12401307700.06600185190.6771825970

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1831784378
GSE13712_SHEARDown-2.0697048009
GSE13712_STATICDown-0.9254573948
GSE19018Down-0.1844259316
GSE19899_A1Up1.9534359556
GSE19899_A2Up2.0934581353
PubMed_21979375_A1Up3.5735432205
PubMed_21979375_A2Up3.9654803076
GSE35957Up0.1616285015
GSE36640Up0.8045987650
GSE54402Up3.3419460003
GSE9593Up0.3840748414
GSE43922Up1.7734522230
GSE24585Down-1.9194677758
GSE37065Down-0.0109110323
GSE28863_A1Down-0.2805962756
GSE28863_A2Down-0.1485229704
GSE28863_A3Up0.4452369738
GSE28863_A4Up0.1863822500
GSE48662Up0.1258796995

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017049MicroarrayFunctional MTI (Weak)18185580
hsa-miR-375MIMAT0000728MIRT019763MicroarrayFunctional MTI (Weak)20215506
hsa-miR-30b-5pMIMAT0000420MIRT046126CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.