HCSGD entry for GATA2

1. General information

Official gene symbolGATA2
Entrez ID2624
Gene full nameGATA binding protein 2
Other gene symbolsDCML MONOMAC NFE1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001158Enhancer sequence-specific DNA bindingIDAmolecular_function
GO:0001655Urogenital system developmentIEAbiological_process
GO:0001709Cell fate determinationIEAbiological_process
GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0003682Chromatin bindingIDA IEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIDAbiological_process
GO:0006909PhagocytosisIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0021514Ventral spinal cord interneuron differentiationIEAbiological_process
GO:0021533Cell differentiation in hindbrainIEAbiological_process
GO:0021954Central nervous system neuron developmentIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035065Regulation of histone acetylationIEAbiological_process
GO:0035854Eosinophil fate commitmentIDAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0045599Negative regulation of fat cell differentiationIEA IMPbiological_process
GO:0045648Positive regulation of erythrocyte differentiationIEAbiological_process
GO:0045650Negative regulation of macrophage differentiationIEAbiological_process
GO:0045654Positive regulation of megakaryocyte differentiationIEAbiological_process
GO:0045746Negative regulation of Notch signaling pathwayIDAbiological_process
GO:0045766Positive regulation of angiogenesisIDA IEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IGI IMPbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0048873Homeostasis of number of cells within a tissueIEAbiological_process
GO:0050766Positive regulation of phagocytosisIEA ISSbiological_process
GO:0060216Definitive hemopoiesisIEAbiological_process
GO:0060872Semicircular canal developmentIEAbiological_process
GO:0070345Negative regulation of fat cell proliferationIMPbiological_process
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:2000178Negative regulation of neural precursor cell proliferationIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97432959990.24942045140.99999024730.9590936012

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0743783813
GSE13712_SHEARDown-0.0602838279
GSE13712_STATICDown-0.1182380524
GSE19018Down-0.0626723731
GSE19899_A1Down-0.1341727201
GSE19899_A2Down-0.0962264941
PubMed_21979375_A1Down-0.1978321367
PubMed_21979375_A2Down-0.1386395916
GSE35957Up0.0539406159
GSE36640Down-0.5468435136
GSE54402Down-0.0538071491
GSE9593Down-0.1530349787
GSE43922Up0.0523173292
GSE24585Up0.0429402855
GSE37065Down-0.0630482963
GSE28863_A1Down-0.1464169532
GSE28863_A2Up0.0123954223
GSE28863_A3Down-0.1592194869
GSE28863_A4Down-0.1074788568
GSE48662Down-0.0740340790

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029763MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.