HCSGD entry for GATA2

1. General information

Official gene symbolGATA2
Entrez ID2624
Gene full nameGATA binding protein 2
Other gene symbolsDCML MONOMAC NFE1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001158Enhancer sequence-specific DNA bindingIDAmolecular_function
GO:0001655Urogenital system developmentIEAbiological_process
GO:0001709Cell fate determinationIEAbiological_process
GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0003682Chromatin bindingIDA IEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIDAbiological_process
GO:0006909PhagocytosisIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0021514Ventral spinal cord interneuron differentiationIEAbiological_process
GO:0021533Cell differentiation in hindbrainIEAbiological_process
GO:0021954Central nervous system neuron developmentIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035065Regulation of histone acetylationIEAbiological_process
GO:0035854Eosinophil fate commitmentIDAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0045599Negative regulation of fat cell differentiationIEA IMPbiological_process
GO:0045648Positive regulation of erythrocyte differentiationIEAbiological_process
GO:0045650Negative regulation of macrophage differentiationIEAbiological_process
GO:0045654Positive regulation of megakaryocyte differentiationIEAbiological_process
GO:0045746Negative regulation of Notch signaling pathwayIDAbiological_process
GO:0045766Positive regulation of angiogenesisIDA IEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IGI IMPbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0048873Homeostasis of number of cells within a tissueIEAbiological_process
GO:0050766Positive regulation of phagocytosisIEA ISSbiological_process
GO:0060216Definitive hemopoiesisIEAbiological_process
GO:0060872Semicircular canal developmentIEAbiological_process
GO:0070345Negative regulation of fat cell proliferationIMPbiological_process
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:2000178Negative regulation of neural precursor cell proliferationIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97432959990.24942045140.99999024730.9590936012

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0743783813
GSE13712_SHEARDown-0.0602838279
GSE13712_STATICDown-0.1182380524
GSE19018Down-0.0626723731
GSE19899_A1Down-0.1341727201
GSE19899_A2Down-0.0962264941
PubMed_21979375_A1Down-0.1978321367
PubMed_21979375_A2Down-0.1386395916
GSE35957Up0.0539406159
GSE36640Down-0.5468435136
GSE54402Down-0.0538071491
GSE9593Down-0.1530349787
GSE43922Up0.0523173292
GSE24585Up0.0429402855
GSE37065Down-0.0630482963
GSE28863_A1Down-0.1464169532
GSE28863_A2Up0.0123954223
GSE28863_A3Down-0.1592194869
GSE28863_A4Down-0.1074788568
GSE48662Down-0.0740340790

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029763MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.