HCSGD entry for AMELX

1. General information

Official gene symbolAMELX
Entrez ID265
Gene full nameamelogenin, X-linked
Other gene symbolsAI1E AIH1 ALGN AMG AMGL AMGX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001649Osteoblast differentiationISSbiological_process
GO:0001837Epithelial to mesenchymal transitionISSbiological_process
GO:0002062Chondrocyte differentiationISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005578Proteinaceous extracellular matrixIDAcellular_component
GO:0007155Cell adhesionISSbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008083Growth factor activityISSmolecular_function
GO:0008283Cell proliferationISSbiological_process
GO:0009986Cell surfaceISScellular_component
GO:0030345Structural constituent of tooth enamelIDA IMPmolecular_function
GO:0031214Biomineral tissue developmentTASbiological_process
GO:0032967Positive regulation of collagen biosynthetic processISSbiological_process
GO:0034505Tooth mineralizationIMP ISSbiological_process
GO:0042475Odontogenesis of dentin-containing toothISSbiological_process
GO:0042802Identical protein bindingISSmolecular_function
GO:0046848Hydroxyapatite bindingISSmolecular_function
GO:0050801Ion homeostasisTASbiological_process
GO:0070166Enamel mineralizationIMPbiological_process
GO:0070172Positive regulation of tooth mineralizationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51797661940.90165176850.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0317417689
GSE13712_SHEARDown-0.0747651490
GSE13712_STATICDown-0.0159778424
GSE19018Down-0.0553533111
GSE19899_A1Up0.2434816968
GSE19899_A2Up0.1006679536
PubMed_21979375_A1Up0.1088434533
PubMed_21979375_A2Up0.0527952506
GSE35957Up0.0460926776
GSE36640Up0.0108878965
GSE54402Up0.1040259512
GSE9593Down-0.0861497035
GSE43922Up0.0183828094
GSE24585Up0.0662889669
GSE37065Up0.0826853005
GSE28863_A1Up0.0353396735
GSE28863_A2Up0.0361145212
GSE28863_A3Up0.2158188902
GSE28863_A4Up0.0104651949
GSE48662Up0.0011219832

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320aMIMAT0000510MIRT044727CLASHFunctional MTI (Weak)23622248
hsa-miR-148a-3pMIMAT0000243MIRT048030CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24989836Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer
24989836We used in vitro and in vivo xenograft models of prostate cancer (PCA) to test whether combination of HDACIs with the pan-aurora kinase inhibitor AMG 900 can synergistically or additively kill PCA cells
24989836AMG 900 and HDACIs synergistically decreased cell proliferation activity and clonogenic survival in DU-145, LNCaP, and PC3 PCA cell lines compared to single-agent treatment
24989836In vivo xenograft studies indicated decreased tumor growth and decreased aurora B kinase activity in mice treated with low-dose AMG 900 and vorinostat compared to either agent alone
24989836Our results indicate that combination treatment with low doses of AMG 900 and HDACIs could be a promising therapy for future clinical trials against PCA
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