HCSGD entry for AMELX
1. General information
| Official gene symbol | AMELX |
|---|---|
| Entrez ID | 265 |
| Gene full name | amelogenin, X-linked |
| Other gene symbols | AI1E AIH1 ALGN AMG AMGL AMGX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001649 | Osteoblast differentiation | ISS | biological_process |
| GO:0001837 | Epithelial to mesenchymal transition | ISS | biological_process |
| GO:0002062 | Chondrocyte differentiation | ISS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | IDA | cellular_component |
| GO:0007155 | Cell adhesion | ISS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008083 | Growth factor activity | ISS | molecular_function |
| GO:0008283 | Cell proliferation | ISS | biological_process |
| GO:0009986 | Cell surface | ISS | cellular_component |
| GO:0030345 | Structural constituent of tooth enamel | IDA IMP | molecular_function |
| GO:0031214 | Biomineral tissue development | TAS | biological_process |
| GO:0032967 | Positive regulation of collagen biosynthetic process | ISS | biological_process |
| GO:0034505 | Tooth mineralization | IMP ISS | biological_process |
| GO:0042475 | Odontogenesis of dentin-containing tooth | ISS | biological_process |
| GO:0042802 | Identical protein binding | ISS | molecular_function |
| GO:0046848 | Hydroxyapatite binding | ISS | molecular_function |
| GO:0050801 | Ion homeostasis | TAS | biological_process |
| GO:0070166 | Enamel mineralization | IMP | biological_process |
| GO:0070172 | Positive regulation of tooth mineralization | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5179766194 | 0.9016517685 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0317417689 |
| GSE13712_SHEAR | Down | -0.0747651490 |
| GSE13712_STATIC | Down | -0.0159778424 |
| GSE19018 | Down | -0.0553533111 |
| GSE19899_A1 | Up | 0.2434816968 |
| GSE19899_A2 | Up | 0.1006679536 |
| PubMed_21979375_A1 | Up | 0.1088434533 |
| PubMed_21979375_A2 | Up | 0.0527952506 |
| GSE35957 | Up | 0.0460926776 |
| GSE36640 | Up | 0.0108878965 |
| GSE54402 | Up | 0.1040259512 |
| GSE9593 | Down | -0.0861497035 |
| GSE43922 | Up | 0.0183828094 |
| GSE24585 | Up | 0.0662889669 |
| GSE37065 | Up | 0.0826853005 |
| GSE28863_A1 | Up | 0.0353396735 |
| GSE28863_A2 | Up | 0.0361145212 |
| GSE28863_A3 | Up | 0.2158188902 |
| GSE28863_A4 | Up | 0.0104651949 |
| GSE48662 | Up | 0.0011219832 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320a | MIMAT0000510 | MIRT044727 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT048030 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24989836 | Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer |
| 24989836 | We used in vitro and in vivo xenograft models of prostate cancer (PCA) to test whether combination of HDACIs with the pan-aurora kinase inhibitor AMG 900 can synergistically or additively kill PCA cells |
| 24989836 | AMG 900 and HDACIs synergistically decreased cell proliferation activity and clonogenic survival in DU-145, LNCaP, and PC3 PCA cell lines compared to single-agent treatment |
| 24989836 | In vivo xenograft studies indicated decreased tumor growth and decreased aurora B kinase activity in mice treated with low-dose AMG 900 and vorinostat compared to either agent alone |
| 24989836 | Our results indicate that combination treatment with low doses of AMG 900 and HDACIs could be a promising therapy for future clinical trials against PCA |
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