HCSGD entry for KLK1
1. General information
| Official gene symbol | KLK1 |
|---|---|
| Entrez ID | 3816 |
| Gene full name | kallikrein 1 |
| Other gene symbols | KLKR Klk6 hK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA NAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8207517951 | 0.2431493332 | 0.9999902473 | 0.9492633640 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1594752282 |
| GSE13712_SHEAR | Down | -0.1867606013 |
| GSE13712_STATIC | Down | -0.0468358761 |
| GSE19018 | Down | -0.0220627996 |
| GSE19899_A1 | Down | -0.0205490834 |
| GSE19899_A2 | Up | 0.1767552459 |
| PubMed_21979375_A1 | Down | -0.2454739652 |
| PubMed_21979375_A2 | Down | -0.2172011624 |
| GSE35957 | Up | 0.0280180529 |
| GSE36640 | Down | -0.0147872287 |
| GSE54402 | Down | -0.1053145228 |
| GSE9593 | Up | 0.0552269039 |
| GSE43922 | Up | 0.1486110772 |
| GSE24585 | Up | 0.1194109913 |
| GSE37065 | Up | 0.0607230699 |
| GSE28863_A1 | Down | -0.4760434967 |
| GSE28863_A2 | Down | -0.3846166366 |
| GSE28863_A3 | Up | 0.1399487888 |
| GSE28863_A4 | Up | 0.2668338593 |
| GSE48662 | Up | 0.0121427408 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Aprotinin | DB06692 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | NA | hsa-miR-224 | {ELISA} | {overexpression} | 20180642 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
