HCSGD entry for ARRB2

1. General information

Official gene symbolARRB2
Entrez ID409
Gene full namearrestin, beta 2
Other gene symbolsARB2 ARR2 BARR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001664G-protein coupled receptor bindingIPImolecular_function
GO:0002031G-protein coupled receptor internalizationIDA IMPbiological_process
GO:0002032Desensitization of G-protein coupled receptor protein signaling pathway by arrestinIMPbiological_process
GO:0002092Positive regulation of receptor internalizationIEA IMPbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006309Apoptotic DNA fragmentationIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0015031Protein transportIEAbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016567Protein ubiquitinationIMPbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0031397Negative regulation of protein ubiquitinationIDA IEAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIGIbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0031623Receptor internalizationIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0031691Alpha-1A adrenergic receptor bindingIEAmolecular_function
GO:0031692Alpha-1B adrenergic receptor bindingIEAmolecular_function
GO:0031701Angiotensin receptor bindingIPImolecular_function
GO:0031702Type 1 angiotensin receptor bindingIEAmolecular_function
GO:0031748D1 dopamine receptor bindingIEAmolecular_function
GO:0031762Follicle-stimulating hormone receptor bindingIEAmolecular_function
GO:0031826Type 2A serotonin receptor bindingIEAmolecular_function
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032226Positive regulation of synaptic transmission, dopaminergicIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032691Negative regulation of interleukin-1 beta productionIEAbiological_process
GO:0032695Negative regulation of interleukin-12 productionIEAbiological_process
GO:0032715Negative regulation of interleukin-6 productionIEAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0032947Protein complex scaffoldIDAmolecular_function
GO:0034122Negative regulation of toll-like receptor signaling pathwayIEAbiological_process
GO:0034260Negative regulation of GTPase activityIEAbiological_process
GO:0034392Negative regulation of smooth muscle cell apoptotic processIEAbiological_process
GO:0042699Follicle-stimulating hormone signaling pathwayIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0043197Dendritic spineIEAcellular_component
GO:0043422Protein kinase B bindingIEAmolecular_function
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045953Negative regulation of natural killer cell mediated cytotoxicityIMPbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050965Detection of temperature stimulus involved in sensory perception of painIEAbiological_process
GO:0051019Mitogen-activated protein kinase bindingIEAmolecular_function
GO:0051897Positive regulation of protein kinase B signalingIEAbiological_process
GO:0051928Positive regulation of calcium ion transportIEAbiological_process
GO:0060326Cell chemotaxisIMPbiological_process
GO:0060765Regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA IEA IMPbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIEAbiological_process
GO:2000573Positive regulation of DNA biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74272106300.09923769610.99999024730.6031021473

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0421377414
GSE13712_SHEARDown-0.3898970201
GSE13712_STATICDown-0.0140874395
GSE19018Up0.2284075523
GSE19899_A1Up0.0448259642
GSE19899_A2Up0.0021706064
PubMed_21979375_A1Down-0.0496903574
PubMed_21979375_A2Down-0.1606055218
GSE35957Down-0.6026264034
GSE36640Down-1.6072955386
GSE54402Down-0.1623495217
GSE9593Down-0.8900633432
GSE43922Up0.0563960445
GSE24585Down-0.3202647678
GSE37065Up0.0555390643
GSE28863_A1Down-0.0390470187
GSE28863_A2Down-0.1507571671
GSE28863_A3Up0.1386953584
GSE28863_A4Up0.0667981219
GSE48662Up0.7485185596

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-330-5pMIMAT0004693MIRT038258CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039876CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045486CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.