HCSGD entry for ARRB2

1. General information

Official gene symbolARRB2
Entrez ID409
Gene full namearrestin, beta 2
Other gene symbolsARB2 ARR2 BARR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001664G-protein coupled receptor bindingIPImolecular_function
GO:0002031G-protein coupled receptor internalizationIDA IMPbiological_process
GO:0002032Desensitization of G-protein coupled receptor protein signaling pathway by arrestinIMPbiological_process
GO:0002092Positive regulation of receptor internalizationIEA IMPbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006309Apoptotic DNA fragmentationIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0015031Protein transportIEAbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016567Protein ubiquitinationIMPbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0031397Negative regulation of protein ubiquitinationIDA IEAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIGIbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0031623Receptor internalizationIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0031691Alpha-1A adrenergic receptor bindingIEAmolecular_function
GO:0031692Alpha-1B adrenergic receptor bindingIEAmolecular_function
GO:0031701Angiotensin receptor bindingIPImolecular_function
GO:0031702Type 1 angiotensin receptor bindingIEAmolecular_function
GO:0031748D1 dopamine receptor bindingIEAmolecular_function
GO:0031762Follicle-stimulating hormone receptor bindingIEAmolecular_function
GO:0031826Type 2A serotonin receptor bindingIEAmolecular_function
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032226Positive regulation of synaptic transmission, dopaminergicIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032691Negative regulation of interleukin-1 beta productionIEAbiological_process
GO:0032695Negative regulation of interleukin-12 productionIEAbiological_process
GO:0032715Negative regulation of interleukin-6 productionIEAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0032947Protein complex scaffoldIDAmolecular_function
GO:0034122Negative regulation of toll-like receptor signaling pathwayIEAbiological_process
GO:0034260Negative regulation of GTPase activityIEAbiological_process
GO:0034392Negative regulation of smooth muscle cell apoptotic processIEAbiological_process
GO:0042699Follicle-stimulating hormone signaling pathwayIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0043197Dendritic spineIEAcellular_component
GO:0043422Protein kinase B bindingIEAmolecular_function
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045953Negative regulation of natural killer cell mediated cytotoxicityIMPbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050965Detection of temperature stimulus involved in sensory perception of painIEAbiological_process
GO:0051019Mitogen-activated protein kinase bindingIEAmolecular_function
GO:0051897Positive regulation of protein kinase B signalingIEAbiological_process
GO:0051928Positive regulation of calcium ion transportIEAbiological_process
GO:0060326Cell chemotaxisIMPbiological_process
GO:0060765Regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA IEA IMPbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIEAbiological_process
GO:2000573Positive regulation of DNA biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74272106300.09923769610.99999024730.6031021473

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0421377414
GSE13712_SHEARDown-0.3898970201
GSE13712_STATICDown-0.0140874395
GSE19018Up0.2284075523
GSE19899_A1Up0.0448259642
GSE19899_A2Up0.0021706064
PubMed_21979375_A1Down-0.0496903574
PubMed_21979375_A2Down-0.1606055218
GSE35957Down-0.6026264034
GSE36640Down-1.6072955386
GSE54402Down-0.1623495217
GSE9593Down-0.8900633432
GSE43922Up0.0563960445
GSE24585Down-0.3202647678
GSE37065Up0.0555390643
GSE28863_A1Down-0.0390470187
GSE28863_A2Down-0.1507571671
GSE28863_A3Up0.1386953584
GSE28863_A4Up0.0667981219
GSE48662Up0.7485185596

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-330-5pMIMAT0004693MIRT038258CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039876CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045486CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.