HCSGD entry for MTHFR

1. General information

Official gene symbolMTHFR
Entrez ID4524
Gene full namemethylenetetrahydrofolate reductase (NAD(P)H)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0004489Methylenetetrahydrofolate reductase (NAD(P)H) activityIEA TASmolecular_function
GO:0005829CytosolIEA TAScellular_component
GO:0006520Cellular amino acid metabolic processTASbiological_process
GO:0006555Methionine metabolic processIEAbiological_process
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0008015Blood circulationTASbiological_process
GO:0009086Methionine biosynthetic processIEAbiological_process
GO:0033274Response to vitamin B2IEAbiological_process
GO:0035999Tetrahydrofolate interconversionIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046500S-adenosylmethionine metabolic processIEAbiological_process
GO:0046653Tetrahydrofolate metabolic processIEAbiological_process
GO:0046655Folic acid metabolic processTASbiological_process
GO:0050660Flavin adenine dinucleotide bindingIEAmolecular_function
GO:0050661NADP bindingIEAmolecular_function
GO:0050667Homocysteine metabolic processIDA IEAbiological_process
GO:0051593Response to folic acidIEAbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0072341Modified amino acid bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26805843620.79089276240.96519372091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0364648843
GSE13712_SHEARDown-0.1378989612
GSE13712_STATICDown-0.2867347247
GSE19018Up0.1888160781
GSE19899_A1Down-0.0174196493
GSE19899_A2Up0.0972294195
PubMed_21979375_A1Down-0.1936311559
PubMed_21979375_A2Up0.1617131485
GSE35957Up0.1131513791
GSE36640Up0.2511671919
GSE54402Down-0.2183285796
GSE9593Up0.2384710107
GSE43922Down-0.0386780835
GSE24585Up0.3295112094
GSE37065Up0.1031167059
GSE28863_A1Up0.5702238222
GSE28863_A2Up0.5200942273
GSE28863_A3Down-0.1509588413
GSE28863_A4Down-0.0965971959
GSE48662Up0.0217409112

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CyanocobalaminDB00115 NUTR00004 | APRD00326 | EXPT00965
Tetrahydrofolic acidDB00116 NUTR00056

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-103a-3pMIMAT0000101MIRT027114SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031648SequencingFunctional MTI (Weak)20371350
hsa-miR-423-3pMIMAT0001340MIRT042604CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21169404Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
21169404Mice heterozygous for the gene deletion of methylenetetrahydrofolate reductase (Mthfr(+/-)) have a 1
21169404Mthfr deficiency was also associated with increased ROS production and reduced nitric oxide (NO) generation in Mthfr(+/-) EPCs
21169404Impaired differentiation of EPCs induced by Mthfr deficiency correlated with increased senescence, decreased telomere length, and reduced expression of SIRT1
21169404Taken together, these results demonstrate that Mthfr deficiency impairs EPC formation and increases EPC senescence by eNOS uncoupling and downregulation of SIRT1
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