HCSGD entry for MTHFR
1. General information
| Official gene symbol | MTHFR |
|---|---|
| Entrez ID | 4524 |
| Gene full name | methylenetetrahydrofolate reductase (NAD(P)H) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0004489 | Methylenetetrahydrofolate reductase (NAD(P)H) activity | IEA TAS | molecular_function |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0006520 | Cellular amino acid metabolic process | TAS | biological_process |
| GO:0006555 | Methionine metabolic process | IEA | biological_process |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0008015 | Blood circulation | TAS | biological_process |
| GO:0009086 | Methionine biosynthetic process | IEA | biological_process |
| GO:0033274 | Response to vitamin B2 | IEA | biological_process |
| GO:0035999 | Tetrahydrofolate interconversion | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046500 | S-adenosylmethionine metabolic process | IEA | biological_process |
| GO:0046653 | Tetrahydrofolate metabolic process | IEA | biological_process |
| GO:0046655 | Folic acid metabolic process | TAS | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0050661 | NADP binding | IEA | molecular_function |
| GO:0050667 | Homocysteine metabolic process | IDA IEA | biological_process |
| GO:0051593 | Response to folic acid | IEA | biological_process |
| GO:0070555 | Response to interleukin-1 | IEA | biological_process |
| GO:0072341 | Modified amino acid binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2680584362 | 0.7908927624 | 0.9651937209 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0364648843 |
| GSE13712_SHEAR | Down | -0.1378989612 |
| GSE13712_STATIC | Down | -0.2867347247 |
| GSE19018 | Up | 0.1888160781 |
| GSE19899_A1 | Down | -0.0174196493 |
| GSE19899_A2 | Up | 0.0972294195 |
| PubMed_21979375_A1 | Down | -0.1936311559 |
| PubMed_21979375_A2 | Up | 0.1617131485 |
| GSE35957 | Up | 0.1131513791 |
| GSE36640 | Up | 0.2511671919 |
| GSE54402 | Down | -0.2183285796 |
| GSE9593 | Up | 0.2384710107 |
| GSE43922 | Down | -0.0386780835 |
| GSE24585 | Up | 0.3295112094 |
| GSE37065 | Up | 0.1031167059 |
| GSE28863_A1 | Up | 0.5702238222 |
| GSE28863_A2 | Up | 0.5200942273 |
| GSE28863_A3 | Down | -0.1509588413 |
| GSE28863_A4 | Down | -0.0965971959 |
| GSE48662 | Up | 0.0217409112 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Cyanocobalamin | DB00115 | NUTR00004 | APRD00326 | EXPT00965 |
| Tetrahydrofolic acid | DB00116 | NUTR00056 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027114 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031648 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042604 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21169404 | Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1 |
| 21169404 | Mice heterozygous for the gene deletion of methylenetetrahydrofolate reductase (Mthfr(+/-)) have a 1 |
| 21169404 | Mthfr deficiency was also associated with increased ROS production and reduced nitric oxide (NO) generation in Mthfr(+/-) EPCs |
| 21169404 | Impaired differentiation of EPCs induced by Mthfr deficiency correlated with increased senescence, decreased telomere length, and reduced expression of SIRT1 |
| 21169404 | Taken together, these results demonstrate that Mthfr deficiency impairs EPC formation and increases EPC senescence by eNOS uncoupling and downregulation of SIRT1 |
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