HCSGD entry for P2RX4

1. General information

Official gene symbolP2RX4
Entrez ID5025
Gene full namepurinergic receptor P2X, ligand-gated ion channel, 4
Other gene symbolsP2X4 P2X4R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001614Purinergic nucleotide receptor activityIDA IEA IMPmolecular_function
GO:0001894Tissue homeostasisNASbiological_process
GO:0002028Regulation of sodium ion transportIEA ISSbiological_process
GO:0004931Extracellular ATP-gated cation channel activityIDA IEAmolecular_function
GO:0005102Receptor bindingIEA ISSmolecular_function
GO:0005216Ion channel activityIEAmolecular_function
GO:0005507Copper ion bindingIEA ISSmolecular_function
GO:0005524ATP bindingIC IEAmolecular_function
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0005887Integral component of plasma membraneICcellular_component
GO:0006809Nitric oxide biosynthetic processIEAbiological_process
GO:0006810TransportIDAbiological_process
GO:0006812Cation transportIDAbiological_process
GO:0006816Calcium ion transportIEAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008217Regulation of blood pressureIMPbiological_process
GO:0008270Zinc ion bindingIEA ISSmolecular_function
GO:0010524Positive regulation of calcium ion transport into cytosolIDA IMPbiological_process
GO:0010614Negative regulation of cardiac muscle hypertrophyIMPbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016020MembraneIDA IEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019228Neuronal action potentialIEAbiological_process
GO:0019233Sensory perception of painIEA ISSbiological_process
GO:0030054Cell junctionIDAcellular_component
GO:0032308Positive regulation of prostaglandin secretionNASbiological_process
GO:0033198Response to ATPIDAbiological_process
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0034405Response to fluid shear stressIDAbiological_process
GO:0035590Purinergic nucleotide receptor signaling pathwayIMPbiological_process
GO:0042118Endothelial cell activationTASbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0045177Apical part of cellIEAcellular_component
GO:0045296Cadherin bindingIPImolecular_function
GO:0045429Positive regulation of nitric oxide biosynthetic processNASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050850Positive regulation of calcium-mediated signalingIDA IMPbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051899Membrane depolarizationIDAbiological_process
GO:0051928Positive regulation of calcium ion transportNASbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0055117Regulation of cardiac muscle contractionIMPbiological_process
GO:0055119Relaxation of cardiac muscleIMPbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0097190Apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38090727180.17578945330.99999024730.8114078204

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0049538709
GSE13712_SHEARDown-0.0183191432
GSE13712_STATICUp0.2171380962
GSE19018Up0.0082100872
GSE19899_A1Down-0.4128887222
GSE19899_A2Down-0.1095163502
PubMed_21979375_A1Down-0.3082677316
PubMed_21979375_A2Down-1.2441489186
GSE35957Down-1.0788560661
GSE36640Down-0.0488462011
GSE54402Down-0.2091457537
GSE9593Up0.9545870178
GSE43922Down-0.0913952922
GSE24585Up0.2923361325
GSE37065Up0.5088969885
GSE28863_A1Up0.1473874718
GSE28863_A2Up0.2010309523
GSE28863_A3Down-0.3212957558
GSE28863_A4Up0.0119409732
GSE48662Up0.3206069780

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Eslicarbazepine acetateDB09119 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017849MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.