HCSGD entry for P2RX4

1. General information

Official gene symbolP2RX4
Entrez ID5025
Gene full namepurinergic receptor P2X, ligand-gated ion channel, 4
Other gene symbolsP2X4 P2X4R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001614Purinergic nucleotide receptor activityIDA IEA IMPmolecular_function
GO:0001894Tissue homeostasisNASbiological_process
GO:0002028Regulation of sodium ion transportIEA ISSbiological_process
GO:0004931Extracellular ATP-gated cation channel activityIDA IEAmolecular_function
GO:0005102Receptor bindingIEA ISSmolecular_function
GO:0005216Ion channel activityIEAmolecular_function
GO:0005507Copper ion bindingIEA ISSmolecular_function
GO:0005524ATP bindingIC IEAmolecular_function
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0005887Integral component of plasma membraneICcellular_component
GO:0006809Nitric oxide biosynthetic processIEAbiological_process
GO:0006810TransportIDAbiological_process
GO:0006812Cation transportIDAbiological_process
GO:0006816Calcium ion transportIEAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008217Regulation of blood pressureIMPbiological_process
GO:0008270Zinc ion bindingIEA ISSmolecular_function
GO:0010524Positive regulation of calcium ion transport into cytosolIDA IMPbiological_process
GO:0010614Negative regulation of cardiac muscle hypertrophyIMPbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016020MembraneIDA IEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019228Neuronal action potentialIEAbiological_process
GO:0019233Sensory perception of painIEA ISSbiological_process
GO:0030054Cell junctionIDAcellular_component
GO:0032308Positive regulation of prostaglandin secretionNASbiological_process
GO:0033198Response to ATPIDAbiological_process
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0034405Response to fluid shear stressIDAbiological_process
GO:0035590Purinergic nucleotide receptor signaling pathwayIMPbiological_process
GO:0042118Endothelial cell activationTASbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0045177Apical part of cellIEAcellular_component
GO:0045296Cadherin bindingIPImolecular_function
GO:0045429Positive regulation of nitric oxide biosynthetic processNASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050850Positive regulation of calcium-mediated signalingIDA IMPbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051899Membrane depolarizationIDAbiological_process
GO:0051928Positive regulation of calcium ion transportNASbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0055117Regulation of cardiac muscle contractionIMPbiological_process
GO:0055119Relaxation of cardiac muscleIMPbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0097190Apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38090727180.17578945330.99999024730.8114078204

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0049538709
GSE13712_SHEARDown-0.0183191432
GSE13712_STATICUp0.2171380962
GSE19018Up0.0082100872
GSE19899_A1Down-0.4128887222
GSE19899_A2Down-0.1095163502
PubMed_21979375_A1Down-0.3082677316
PubMed_21979375_A2Down-1.2441489186
GSE35957Down-1.0788560661
GSE36640Down-0.0488462011
GSE54402Down-0.2091457537
GSE9593Up0.9545870178
GSE43922Down-0.0913952922
GSE24585Up0.2923361325
GSE37065Up0.5088969885
GSE28863_A1Up0.1473874718
GSE28863_A2Up0.2010309523
GSE28863_A3Down-0.3212957558
GSE28863_A4Up0.0119409732
GSE48662Up0.3206069780

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Eslicarbazepine acetateDB09119 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017849MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.