HCSGD entry for PLA2G4A
1. General information
| Official gene symbol | PLA2G4A |
|---|---|
| Entrez ID | 5321 |
| Gene full name | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
| Other gene symbols | PLA2G4 cPLA2-alpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004620 | Phospholipase activity | IEA | molecular_function |
| GO:0004622 | Lysophospholipase activity | IEA | molecular_function |
| GO:0004623 | Phospholipase A2 activity | IDA NAS TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IDA | molecular_function |
| GO:0005544 | Calcium-dependent phospholipid binding | IDA | molecular_function |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005829 | Cytosol | NAS TAS | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006654 | Phosphatidic acid biosynthetic process | TAS | biological_process |
| GO:0006663 | Platelet activating factor biosynthetic process | NAS | biological_process |
| GO:0006690 | Icosanoid metabolic process | NAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009395 | Phospholipid catabolic process | IEA | biological_process |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0035965 | Cardiolipin acyl-chain remodeling | TAS | biological_process |
| GO:0036148 | Phosphatidylglycerol acyl-chain remodeling | TAS | biological_process |
| GO:0036149 | Phosphatidylinositol acyl-chain remodeling | TAS | biological_process |
| GO:0036150 | Phosphatidylserine acyl-chain remodeling | TAS | biological_process |
| GO:0036151 | Phosphatidylcholine acyl-chain remodeling | TAS | biological_process |
| GO:0036152 | Phosphatidylethanolamine acyl-chain remodeling | TAS | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046456 | Icosanoid biosynthetic process | IEA | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0047498 | Calcium-dependent phospholipase A2 activity | EXP | molecular_function |
| GO:0050482 | Arachidonic acid secretion | IEA | biological_process |
| GO:0071236 | Cellular response to antibiotic | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0002855971 | 0.1682246305 | 0.0455648485 | 0.7930220591 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.2228261119 |
| GSE13712_SHEAR | Up | 0.5808885395 |
| GSE13712_STATIC | Up | 1.1092968023 |
| GSE19018 | Down | -0.5156615027 |
| GSE19899_A1 | Up | 1.0988578477 |
| GSE19899_A2 | Up | 1.1607313525 |
| PubMed_21979375_A1 | Up | 3.8402705515 |
| PubMed_21979375_A2 | Up | 3.9790362399 |
| GSE35957 | Down | -3.4271005003 |
| GSE36640 | Down | -0.5075675350 |
| GSE54402 | Up | 0.7575563417 |
| GSE9593 | Down | -1.4650642241 |
| GSE43922 | Up | 1.4753122902 |
| GSE24585 | Up | 0.5247939134 |
| GSE37065 | Up | 1.2661602378 |
| GSE28863_A1 | Down | -0.1678403360 |
| GSE28863_A2 | Down | -0.0329263129 |
| GSE28863_A3 | Up | 0.0281932291 |
| GSE28863_A4 | Up | 0.6526085148 |
| GSE48662 | Down | -1.2683836327 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022551 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028507 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-146b-5p | MIMAT0002809 | MIRT041616 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047518 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-449c-5p | MIMAT0010251 | MIRT052653 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
