HCSGD entry for PLA2G4A

1. General information

Official gene symbolPLA2G4A
Entrez ID5321
Gene full namephospholipase A2, group IVA (cytosolic, calcium-dependent)
Other gene symbolsPLA2G4 cPLA2-alpha
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004620Phospholipase activityIEAmolecular_function
GO:0004622Lysophospholipase activityIEAmolecular_function
GO:0004623Phospholipase A2 activityIDA NAS TASmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005544Calcium-dependent phospholipid bindingIDAmolecular_function
GO:0005743Mitochondrial inner membraneTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolNAS TAScellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006654Phosphatidic acid biosynthetic processTASbiological_process
GO:0006663Platelet activating factor biosynthetic processNASbiological_process
GO:0006690Icosanoid metabolic processNASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0009395Phospholipid catabolic processIEAbiological_process
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0035965Cardiolipin acyl-chain remodelingTASbiological_process
GO:0036148Phosphatidylglycerol acyl-chain remodelingTASbiological_process
GO:0036149Phosphatidylinositol acyl-chain remodelingTASbiological_process
GO:0036150Phosphatidylserine acyl-chain remodelingTASbiological_process
GO:0036151Phosphatidylcholine acyl-chain remodelingTASbiological_process
GO:0036152Phosphatidylethanolamine acyl-chain remodelingTASbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046456Icosanoid biosynthetic processIEAbiological_process
GO:0046474Glycerophospholipid biosynthetic processTASbiological_process
GO:0047498Calcium-dependent phospholipase A2 activityEXPmolecular_function
GO:0050482Arachidonic acid secretionIEAbiological_process
GO:0071236Cellular response to antibioticIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00028559710.16822463050.04556484850.7930220591

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.2228261119
GSE13712_SHEARUp0.5808885395
GSE13712_STATICUp1.1092968023
GSE19018Down-0.5156615027
GSE19899_A1Up1.0988578477
GSE19899_A2Up1.1607313525
PubMed_21979375_A1Up3.8402705515
PubMed_21979375_A2Up3.9790362399
GSE35957Down-3.4271005003
GSE36640Down-0.5075675350
GSE54402Up0.7575563417
GSE9593Down-1.4650642241
GSE43922Up1.4753122902
GSE24585Up0.5247939134
GSE37065Up1.2661602378
GSE28863_A1Down-0.1678403360
GSE28863_A2Down-0.0329263129
GSE28863_A3Up0.0281932291
GSE28863_A4Up0.6526085148
GSE48662Down-1.2683836327

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Fluticasone PropionateDB00588 APRD00065
Niflumic AcidDB04552 EXPT02331

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022551MicroarrayFunctional MTI (Weak)18668037
hsa-miR-30a-5pMIMAT0000087MIRT028507ProteomicsFunctional MTI (Weak)18668040
hsa-miR-146b-5pMIMAT0002809MIRT041616CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047518CLASHFunctional MTI (Weak)23622248
hsa-miR-449c-5pMIMAT0010251MIRT052653CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.