HCSGD entry for ATP7A

1. General information

Official gene symbolATP7A
Entrez ID538
Gene full nameATPase, Cu++ transporting, alpha polypeptide
Other gene symbolsDSMAX MK MNK SMAX3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001568Blood vessel developmentISSbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001836Release of cytochrome c from mitochondriaIEAbiological_process
GO:0001974Blood vessel remodelingISSbiological_process
GO:0002082Regulation of oxidative phosphorylationISSbiological_process
GO:0004008Copper-exporting ATPase activityISSmolecular_function
GO:0005375Copper ion transmembrane transporter activityISSmolecular_function
GO:0005507Copper ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingTASmolecular_function
GO:0005770Late endosomeIDAcellular_component
GO:0005783Endoplasmic reticulumIDA IEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0006568Tryptophan metabolic processISSbiological_process
GO:0006570Tyrosine metabolic processIEAbiological_process
GO:0006584Catecholamine metabolic processISSbiological_process
GO:0006825Copper ion transportIMPbiological_process
GO:0006878Cellular copper ion homeostasisIMPbiological_process
GO:0007005Mitochondrion organizationISSbiological_process
GO:0007595LactationIEAbiological_process
GO:0007626Locomotory behaviorISSbiological_process
GO:0010041Response to iron(III) ionIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0010273Detoxification of copper ionISSbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0015677Copper ion importISSbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016532Superoxide dismutase copper chaperone activityISSmolecular_function
GO:0018205Peptidyl-lysine modificationISSbiological_process
GO:0019430Removal of superoxide radicalsISSbiological_process
GO:0021702Cerebellar Purkinje cell differentiationISSbiological_process
GO:0021860Pyramidal neuron developmentISSbiological_process
GO:0021954Central nervous system neuron developmentISSbiological_process
GO:0030140Trans-Golgi network transport vesicleIMPcellular_component
GO:0030141Secretory granuleIEAcellular_component
GO:0030198Extracellular matrix organizationISSbiological_process
GO:0030199Collagen fibril organizationISSbiological_process
GO:0031069Hair follicle morphogenesisISSbiological_process
GO:0031526Brush border membraneIEAcellular_component
GO:0032767Copper-dependent protein bindingIPImolecular_function
GO:0034220Ion transmembrane transportTASbiological_process
GO:0042093T-helper cell differentiationISSbiological_process
GO:0042414Epinephrine metabolic processISSbiological_process
GO:0042415Norepinephrine metabolic processISSbiological_process
GO:0042417Dopamine metabolic processISSbiological_process
GO:0042421Norepinephrine biosynthetic processIEAbiological_process
GO:0042428Serotonin metabolic processISSbiological_process
GO:0043005Neuron projectionISScellular_component
GO:0043025Neuronal cell bodyISScellular_component
GO:0043085Positive regulation of catalytic activityISSbiological_process
GO:0043473PigmentationISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043588Skin developmentISSbiological_process
GO:0048251Elastic fiber assemblyISSbiological_process
GO:0048286Lung alveolus developmentISSbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048553Negative regulation of metalloenzyme activityISSbiological_process
GO:0048554Positive regulation of metalloenzyme activityISSbiological_process
GO:0048812Neuron projection morphogenesisISSbiological_process
GO:0048813Dendrite morphogenesisIEAbiological_process
GO:0051216Cartilage developmentISSbiological_process
GO:0051353Positive regulation of oxidoreductase activityIDAbiological_process
GO:0051542Elastin biosynthetic processISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060003Copper ion exportISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08873594090.47665693170.62466400111.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0242058358
GSE13712_SHEARDown-0.4472646787
GSE13712_STATICDown-0.2438987503
GSE19018Down-0.0551961244
GSE19899_A1Up0.2722162983
GSE19899_A2Down-0.5119595555
PubMed_21979375_A1Up0.3733852739
PubMed_21979375_A2Up0.7351884577
GSE35957Up0.2318772735
GSE36640Up1.5071073202
GSE54402Up0.0772346320
GSE9593Up0.0857979029
GSE43922Up0.2618459909
GSE24585Up0.0808896329
GSE37065Up0.1039831179
GSE28863_A1Down-0.0351807972
GSE28863_A2Down-0.3746148142
GSE28863_A3Down-0.1519228476
GSE28863_A4Down-0.1097048254
GSE48662Up0.3441042574

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018615MicroarrayFunctional MTI (Weak)18185580
hsa-miR-148b-3pMIMAT0000759MIRT019495MicroarrayFunctional MTI (Weak)17612493
hsa-miR-9-5pMIMAT0000441MIRT021461MicroarrayFunctional MTI (Weak)17612493
hsa-miR-122-5pMIMAT0000421MIRT023385MicroarrayFunctional MTI (Weak)17612493
hsa-miR-320aMIMAT0000510MIRT044676CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.