HCSGD entry for ATP7A

1. General information

Official gene symbolATP7A
Entrez ID538
Gene full nameATPase, Cu++ transporting, alpha polypeptide
Other gene symbolsDSMAX MK MNK SMAX3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001568Blood vessel developmentISSbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001836Release of cytochrome c from mitochondriaIEAbiological_process
GO:0001974Blood vessel remodelingISSbiological_process
GO:0002082Regulation of oxidative phosphorylationISSbiological_process
GO:0004008Copper-exporting ATPase activityISSmolecular_function
GO:0005375Copper ion transmembrane transporter activityISSmolecular_function
GO:0005507Copper ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingTASmolecular_function
GO:0005770Late endosomeIDAcellular_component
GO:0005783Endoplasmic reticulumIDA IEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0006568Tryptophan metabolic processISSbiological_process
GO:0006570Tyrosine metabolic processIEAbiological_process
GO:0006584Catecholamine metabolic processISSbiological_process
GO:0006825Copper ion transportIMPbiological_process
GO:0006878Cellular copper ion homeostasisIMPbiological_process
GO:0007005Mitochondrion organizationISSbiological_process
GO:0007595LactationIEAbiological_process
GO:0007626Locomotory behaviorISSbiological_process
GO:0010041Response to iron(III) ionIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0010273Detoxification of copper ionISSbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0015677Copper ion importISSbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016532Superoxide dismutase copper chaperone activityISSmolecular_function
GO:0018205Peptidyl-lysine modificationISSbiological_process
GO:0019430Removal of superoxide radicalsISSbiological_process
GO:0021702Cerebellar Purkinje cell differentiationISSbiological_process
GO:0021860Pyramidal neuron developmentISSbiological_process
GO:0021954Central nervous system neuron developmentISSbiological_process
GO:0030140Trans-Golgi network transport vesicleIMPcellular_component
GO:0030141Secretory granuleIEAcellular_component
GO:0030198Extracellular matrix organizationISSbiological_process
GO:0030199Collagen fibril organizationISSbiological_process
GO:0031069Hair follicle morphogenesisISSbiological_process
GO:0031526Brush border membraneIEAcellular_component
GO:0032767Copper-dependent protein bindingIPImolecular_function
GO:0034220Ion transmembrane transportTASbiological_process
GO:0042093T-helper cell differentiationISSbiological_process
GO:0042414Epinephrine metabolic processISSbiological_process
GO:0042415Norepinephrine metabolic processISSbiological_process
GO:0042417Dopamine metabolic processISSbiological_process
GO:0042421Norepinephrine biosynthetic processIEAbiological_process
GO:0042428Serotonin metabolic processISSbiological_process
GO:0043005Neuron projectionISScellular_component
GO:0043025Neuronal cell bodyISScellular_component
GO:0043085Positive regulation of catalytic activityISSbiological_process
GO:0043473PigmentationISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043588Skin developmentISSbiological_process
GO:0048251Elastic fiber assemblyISSbiological_process
GO:0048286Lung alveolus developmentISSbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048553Negative regulation of metalloenzyme activityISSbiological_process
GO:0048554Positive regulation of metalloenzyme activityISSbiological_process
GO:0048812Neuron projection morphogenesisISSbiological_process
GO:0048813Dendrite morphogenesisIEAbiological_process
GO:0051216Cartilage developmentISSbiological_process
GO:0051353Positive regulation of oxidoreductase activityIDAbiological_process
GO:0051542Elastin biosynthetic processISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060003Copper ion exportISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08873594090.47665693170.62466400111.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0242058358
GSE13712_SHEARDown-0.4472646787
GSE13712_STATICDown-0.2438987503
GSE19018Down-0.0551961244
GSE19899_A1Up0.2722162983
GSE19899_A2Down-0.5119595555
PubMed_21979375_A1Up0.3733852739
PubMed_21979375_A2Up0.7351884577
GSE35957Up0.2318772735
GSE36640Up1.5071073202
GSE54402Up0.0772346320
GSE9593Up0.0857979029
GSE43922Up0.2618459909
GSE24585Up0.0808896329
GSE37065Up0.1039831179
GSE28863_A1Down-0.0351807972
GSE28863_A2Down-0.3746148142
GSE28863_A3Down-0.1519228476
GSE28863_A4Down-0.1097048254
GSE48662Up0.3441042574

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018615MicroarrayFunctional MTI (Weak)18185580
hsa-miR-148b-3pMIMAT0000759MIRT019495MicroarrayFunctional MTI (Weak)17612493
hsa-miR-9-5pMIMAT0000441MIRT021461MicroarrayFunctional MTI (Weak)17612493
hsa-miR-122-5pMIMAT0000421MIRT023385MicroarrayFunctional MTI (Weak)17612493
hsa-miR-320aMIMAT0000510MIRT044676CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.