HCSGD entry for PRKG1

1. General information

Official gene symbolPRKG1
Entrez ID5592
Gene full nameprotein kinase, cGMP-dependent, type I
Other gene symbols1 PKG PRKG1B PRKGR1B cGK cGK 1 cGK1 cGKI cGKI-BETA cGKI-alpha
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001764Neuron migrationIEAbiological_process
GO:0004692CGMP-dependent protein kinase activityIDA IEAmolecular_function
GO:0005246Calcium channel regulator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0016358Dendrite developmentIEAbiological_process
GO:0030036Actin cytoskeleton organizationTASbiological_process
GO:0030553CGMP bindingIEAmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0043087Regulation of GTPase activityIMPbiological_process
GO:0090331Negative regulation of platelet aggregationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33863349800.46239713160.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0935713080
GSE13712_SHEARUp0.0884035054
GSE13712_STATICUp0.2667109688
GSE19018Down-0.0740151767
GSE19899_A1Down-0.4083385623
GSE19899_A2Down-0.2499047560
PubMed_21979375_A1Up0.1157851444
PubMed_21979375_A2Down-0.1186919762
GSE35957Up0.9488581382
GSE36640Up0.0040762677
GSE54402Down-0.5466572512
GSE9593Up0.0833391849
GSE43922Down-0.3492483904
GSE24585Up0.3427160132
GSE37065Up0.4343809351
GSE28863_A1Up0.1353619317
GSE28863_A2Up0.0774013909
GSE28863_A3Down-0.2538844807
GSE28863_A4Up0.1154652470
GSE48662Down-0.0656124446

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

244787902; and RASGEF1A, HNRNPF, ANF487, CSTF2T, and PRKG1 at 10q11
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