HCSGD entry for PRKG1

1. General information

Official gene symbolPRKG1
Entrez ID5592
Gene full nameprotein kinase, cGMP-dependent, type I
Other gene symbols1 PKG PRKG1B PRKGR1B cGK cGK 1 cGK1 cGKI cGKI-BETA cGKI-alpha
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001764Neuron migrationIEAbiological_process
GO:0004692CGMP-dependent protein kinase activityIDA IEAmolecular_function
GO:0005246Calcium channel regulator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0016358Dendrite developmentIEAbiological_process
GO:0030036Actin cytoskeleton organizationTASbiological_process
GO:0030553CGMP bindingIEAmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0043087Regulation of GTPase activityIMPbiological_process
GO:0090331Negative regulation of platelet aggregationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33863349800.46239713160.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0935713080
GSE13712_SHEARUp0.0884035054
GSE13712_STATICUp0.2667109688
GSE19018Down-0.0740151767
GSE19899_A1Down-0.4083385623
GSE19899_A2Down-0.2499047560
PubMed_21979375_A1Up0.1157851444
PubMed_21979375_A2Down-0.1186919762
GSE35957Up0.9488581382
GSE36640Up0.0040762677
GSE54402Down-0.5466572512
GSE9593Up0.0833391849
GSE43922Down-0.3492483904
GSE24585Up0.3427160132
GSE37065Up0.4343809351
GSE28863_A1Up0.1353619317
GSE28863_A2Up0.0774013909
GSE28863_A3Down-0.2538844807
GSE28863_A4Up0.1154652470
GSE48662Down-0.0656124446

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

244787902; and RASGEF1A, HNRNPF, ANF487, CSTF2T, and PRKG1 at 10q11
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