HCSGD entry for RAG1

1. General information

Official gene symbolRAG1
Entrez ID5896
Gene full namerecombination activating gene 1
Other gene symbolsRAG-1 RNF74
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002250Adaptive immune responseIEAbiological_process
GO:0002331Pre-B cell allelic exclusionISSbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0004519Endonuclease activityISSmolecular_function
GO:0004842Ubiquitin-protein ligase activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0006310DNA recombinationTASbiological_process
GO:0006955Immune responseTASbiological_process
GO:0008270Zinc ion bindingIEA ISSmolecular_function
GO:0010390Histone monoubiquitinationISSbiological_process
GO:0016788Hydrolase activity, acting on ester bondsIEAmolecular_function
GO:0016881Acid-amino acid ligase activityIEAmolecular_function
GO:0030183B cell differentiationISSbiological_process
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0033151V(D)J recombinationIEA ISSbiological_process
GO:0042393Histone bindingISSmolecular_function
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043029T cell homeostasisIEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEA ISSmolecular_function
GO:0045580Regulation of T cell differentiationIEAbiological_process
GO:0046872Metal ion bindingISSmolecular_function
GO:0048538Thymus developmentIEAbiological_process
GO:0051865Protein autoubiquitinationISSbiological_process
GO:0070244Negative regulation of thymocyte apoptotic processIEAbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19039332090.89821213100.84792962271.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1283230299
GSE13712_SHEARDown-0.2027267854
GSE13712_STATICUp0.1492831021
GSE19018Up0.5917942387
GSE19899_A1Up0.0709784559
GSE19899_A2Down-0.0941855359
PubMed_21979375_A1Down-0.0325441114
PubMed_21979375_A2Up0.0758908192
GSE35957Up0.2005992391
GSE36640Up0.9105883076
GSE54402Up0.1297958800
GSE9593Up0.2076212514
GSE43922Up0.0152544976
GSE24585Down-0.0367588079
GSE37065Up0.0266894171
GSE28863_A1Down-0.4129730917
GSE28863_A2Down-0.1108836898
GSE28863_A3Up0.1779388597
GSE28863_A4Up0.1615541137
GSE48662Up0.0512375104

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-186-5pMIMAT0000456MIRT045071CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.