HCSGD entry for RAG1

1. General information

Official gene symbolRAG1
Entrez ID5896
Gene full namerecombination activating gene 1
Other gene symbolsRAG-1 RNF74
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002250Adaptive immune responseIEAbiological_process
GO:0002331Pre-B cell allelic exclusionISSbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0004519Endonuclease activityISSmolecular_function
GO:0004842Ubiquitin-protein ligase activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0006310DNA recombinationTASbiological_process
GO:0006955Immune responseTASbiological_process
GO:0008270Zinc ion bindingIEA ISSmolecular_function
GO:0010390Histone monoubiquitinationISSbiological_process
GO:0016788Hydrolase activity, acting on ester bondsIEAmolecular_function
GO:0016881Acid-amino acid ligase activityIEAmolecular_function
GO:0030183B cell differentiationISSbiological_process
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0033151V(D)J recombinationIEA ISSbiological_process
GO:0042393Histone bindingISSmolecular_function
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043029T cell homeostasisIEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEA ISSmolecular_function
GO:0045580Regulation of T cell differentiationIEAbiological_process
GO:0046872Metal ion bindingISSmolecular_function
GO:0048538Thymus developmentIEAbiological_process
GO:0051865Protein autoubiquitinationISSbiological_process
GO:0070244Negative regulation of thymocyte apoptotic processIEAbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19039332090.89821213100.84792962271.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1283230299
GSE13712_SHEARDown-0.2027267854
GSE13712_STATICUp0.1492831021
GSE19018Up0.5917942387
GSE19899_A1Up0.0709784559
GSE19899_A2Down-0.0941855359
PubMed_21979375_A1Down-0.0325441114
PubMed_21979375_A2Up0.0758908192
GSE35957Up0.2005992391
GSE36640Up0.9105883076
GSE54402Up0.1297958800
GSE9593Up0.2076212514
GSE43922Up0.0152544976
GSE24585Down-0.0367588079
GSE37065Up0.0266894171
GSE28863_A1Down-0.4129730917
GSE28863_A2Down-0.1108836898
GSE28863_A3Up0.1779388597
GSE28863_A4Up0.1615541137
GSE48662Up0.0512375104

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-186-5pMIMAT0000456MIRT045071CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.