HCSGD entry for RGS2

1. General information

Official gene symbolRGS2
Entrez ID5997
Gene full nameregulator of G-protein signaling 2, 24kDa
Other gene symbolsG0S8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005096GTPase activator activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingTASmolecular_function
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolISScellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0006417Regulation of translationIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayTASbiological_process
GO:0009898Cytoplasmic side of plasma membraneISScellular_component
GO:0010519Negative regulation of phospholipase activityISSbiological_process
GO:0010614Negative regulation of cardiac muscle hypertrophyISSbiological_process
GO:0031116Positive regulation of microtubule polymerizationIEAbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043407Negative regulation of MAP kinase activityISSbiological_process
GO:0045744Negative regulation of G-protein coupled receptor protein signaling pathwayISSbiological_process
GO:0048487Beta-tubulin bindingIEAmolecular_function
GO:0050873Brown fat cell differentiationIEAbiological_process
GO:0055119Relaxation of cardiac muscleISSbiological_process
GO:0060087Relaxation of vascular smooth muscleIEAbiological_process
GO:0060452Positive regulation of cardiac muscle contractionISSbiological_process
GO:0071877Regulation of adrenergic receptor signaling pathwayISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03650980590.04952131760.43328291250.4165403195

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0634752495
GSE13712_SHEARUp0.0042656299
GSE13712_STATICUp0.4105093715
GSE19018Down-1.3887607535
GSE19899_A1Up0.2401572408
GSE19899_A2Down-1.2765581379
PubMed_21979375_A1Up2.1155550479
PubMed_21979375_A2Up1.2709183315
GSE35957Down-0.4861968163
GSE36640Up0.6728278436
GSE54402Down-0.4444335847
GSE9593Down-0.0784107767
GSE43922Up0.0372668378
GSE24585Up0.0916688310
GSE37065Up0.9448143949
GSE28863_A1Down-0.2179984050
GSE28863_A2Up0.0550052055
GSE28863_A3Down-0.1749540166
GSE28863_A4Up0.1456275083
GSE48662Down-0.4765394843

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-22-3pMIMAT0000077MIRT005903Luciferase reporter assay//MicroarrayFunctional MTI21168126
hsa-miR-22-3pMIMAT0000077MIRT005903Luciferase reporter assayFunctional MTI23349832
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25077541Repression of ADCY5 by miR-17 translocated membrane-bound RGS2 into the nucleus, promoting interactions of RGS2 with HIF1alpha and the MKP7 promoter, enhancing MKP7 transcription
25077541Repression of ADCY5 by miR-17 translocated membrane-bound RGS2 into the nucleus, promoting interactions of RGS2 with HIF1alpha and the MKP7 promoter, enhancing MKP7 transcription
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