HCSGD entry for RGS2

1. General information

Official gene symbolRGS2
Entrez ID5997
Gene full nameregulator of G-protein signaling 2, 24kDa
Other gene symbolsG0S8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005096GTPase activator activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingTASmolecular_function
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolISScellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0006417Regulation of translationIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayTASbiological_process
GO:0009898Cytoplasmic side of plasma membraneISScellular_component
GO:0010519Negative regulation of phospholipase activityISSbiological_process
GO:0010614Negative regulation of cardiac muscle hypertrophyISSbiological_process
GO:0031116Positive regulation of microtubule polymerizationIEAbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043407Negative regulation of MAP kinase activityISSbiological_process
GO:0045744Negative regulation of G-protein coupled receptor protein signaling pathwayISSbiological_process
GO:0048487Beta-tubulin bindingIEAmolecular_function
GO:0050873Brown fat cell differentiationIEAbiological_process
GO:0055119Relaxation of cardiac muscleISSbiological_process
GO:0060087Relaxation of vascular smooth muscleIEAbiological_process
GO:0060452Positive regulation of cardiac muscle contractionISSbiological_process
GO:0071877Regulation of adrenergic receptor signaling pathwayISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03650980590.04952131760.43328291250.4165403195

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0634752495
GSE13712_SHEARUp0.0042656299
GSE13712_STATICUp0.4105093715
GSE19018Down-1.3887607535
GSE19899_A1Up0.2401572408
GSE19899_A2Down-1.2765581379
PubMed_21979375_A1Up2.1155550479
PubMed_21979375_A2Up1.2709183315
GSE35957Down-0.4861968163
GSE36640Up0.6728278436
GSE54402Down-0.4444335847
GSE9593Down-0.0784107767
GSE43922Up0.0372668378
GSE24585Up0.0916688310
GSE37065Up0.9448143949
GSE28863_A1Down-0.2179984050
GSE28863_A2Up0.0550052055
GSE28863_A3Down-0.1749540166
GSE28863_A4Up0.1456275083
GSE48662Down-0.4765394843

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-22-3pMIMAT0000077MIRT005903Luciferase reporter assay//MicroarrayFunctional MTI21168126
hsa-miR-22-3pMIMAT0000077MIRT005903Luciferase reporter assayFunctional MTI23349832
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25077541Repression of ADCY5 by miR-17 translocated membrane-bound RGS2 into the nucleus, promoting interactions of RGS2 with HIF1alpha and the MKP7 promoter, enhancing MKP7 transcription
25077541Repression of ADCY5 by miR-17 translocated membrane-bound RGS2 into the nucleus, promoting interactions of RGS2 with HIF1alpha and the MKP7 promoter, enhancing MKP7 transcription
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