HCSGD entry for ROS1
1. General information
| Official gene symbol | ROS1 |
|---|---|
| Entrez ID | 6098 |
| Gene full name | c-ros oncogene 1 , receptor tyrosine kinase |
| Other gene symbols | MCF3 ROS c-ros-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002066 | Columnar/cuboidal epithelial cell development | ISS | biological_process |
| GO:0004713 | Protein tyrosine kinase activity | IDA | molecular_function |
| GO:0004714 | Transmembrane receptor protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | IEA | biological_process |
| GO:0007283 | Spermatogenesis | ISS | biological_process |
| GO:0008283 | Cell proliferation | ISS | biological_process |
| GO:0010629 | Negative regulation of gene expression | IEA | biological_process |
| GO:0010966 | Regulation of phosphate transport | IEA | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016049 | Cell growth | IDA | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0030154 | Cell differentiation | ISS | biological_process |
| GO:0032006 | Regulation of TOR signaling | IDA | biological_process |
| GO:0070372 | Regulation of ERK1 and ERK2 cascade | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7713111356 | 0.4351701227 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0259812033 |
| GSE13712_SHEAR | Up | 0.0242325246 |
| GSE13712_STATIC | Up | 0.0513041220 |
| GSE19018 | Up | 0.0271000783 |
| GSE19899_A1 | Up | 0.1990694531 |
| GSE19899_A2 | Up | 0.0064394627 |
| PubMed_21979375_A1 | Down | -0.2069495245 |
| PubMed_21979375_A2 | Up | 0.2634016026 |
| GSE35957 | Down | -0.0073723077 |
| GSE36640 | Up | 0.0282163051 |
| GSE54402 | Up | 0.0974914268 |
| GSE9593 | Down | -0.0204716012 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.4258414646 |
| GSE28863_A2 | Down | -0.3121478904 |
| GSE28863_A3 | Down | -0.5075714330 |
| GSE28863_A4 | Up | 0.0929829895 |
| GSE48662 | Up | 0.3540495694 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029292 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
