HCSGD entry for ROS1

1. General information

Official gene symbolROS1
Entrez ID6098
Gene full namec-ros oncogene 1 , receptor tyrosine kinase
Other gene symbolsMCF3 ROS c-ros-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002066Columnar/cuboidal epithelial cell developmentISSbiological_process
GO:0004713Protein tyrosine kinase activityIDAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEAbiological_process
GO:0007283SpermatogenesisISSbiological_process
GO:0008283Cell proliferationISSbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010966Regulation of phosphate transportIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016049Cell growthIDAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030154Cell differentiationISSbiological_process
GO:0032006Regulation of TOR signalingIDAbiological_process
GO:0070372Regulation of ERK1 and ERK2 cascadeISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77131113560.43517012270.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0259812033
GSE13712_SHEARUp0.0242325246
GSE13712_STATICUp0.0513041220
GSE19018Up0.0271000783
GSE19899_A1Up0.1990694531
GSE19899_A2Up0.0064394627
PubMed_21979375_A1Down-0.2069495245
PubMed_21979375_A2Up0.2634016026
GSE35957Down-0.0073723077
GSE36640Up0.0282163051
GSE54402Up0.0974914268
GSE9593Down-0.0204716012
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.4258414646
GSE28863_A2Down-0.3121478904
GSE28863_A3Down-0.5075714330
GSE28863_A4Up0.0929829895
GSE48662Up0.3540495694

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029292MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.