HCSGD entry for TST

1. General information

Official gene symbolTST
Entrez ID7263
Gene full namethiosulfate sulfurtransferase (rhodanese)
Other gene symbolsRDS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000096Sulfur amino acid metabolic processTASbiological_process
GO:0000098Sulfur amino acid catabolic processTASbiological_process
GO:0004792Thiosulfate sulfurtransferase activityIEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:00080975S rRNA bindingIDAmolecular_function
GO:0009440Cyanate catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0035928RRNA import into mitochondrionIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051029RRNA transportIDAbiological_process
GO:0070221Sulfide oxidation, using sulfide:quinone oxidoreductaseTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01546320430.08067543030.30935623100.5371763218

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1660724939
GSE13712_SHEARDown-0.7608272828
GSE13712_STATICDown-0.2353124012
GSE19018Up0.0709169889
GSE19899_A1Up0.8158669827
GSE19899_A2Up1.2578641800
PubMed_21979375_A1Up1.6988683977
PubMed_21979375_A2Up0.7514216969
GSE35957Up1.1668576009
GSE36640Up0.7788493415
GSE54402Up0.3563287268
GSE9593Down-0.3711581738
GSE43922Up0.4400843155
GSE24585Up0.1931382130
GSE37065Down-0.4039019607
GSE28863_A1Down-1.0229865787
GSE28863_A2Down-0.1999135719
GSE28863_A3Down-1.1856895396
GSE28863_A4Up0.1069881136
GSE48662Down-0.1938436846

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

S-MercaptocysteineDB02761 EXPT01038

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-548b-3pMIMAT0003254MIRT016237SequencingFunctional MTI (Weak)20371350
hsa-let-7d-5pMIMAT0000065MIRT032127SequencingFunctional MTI (Weak)20371350
hsa-let-7b-5pMIMAT0000063MIRT032251ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24470704This article describes relationships between telomere length and sleep parameters that included total sleep time (TST), wake after sleep onset (WASO), and self-reported sleep quality in a sample of adults with chronic illness
24470704MEASUREMENTS AND RESULTS: TST and WASO were estimated with wrist actigraphy across 72 h; self-reported sleep quality was assessed with the Pittsburgh Sleep Quality Index
20099848Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis
20099848Rack1, EF-Tu and Rhodanese, three validated differential proteins, were further investigated for their role in the in vitro cell senescence
20099848Taken together, our results suggest that Rack1, EF-Tu and Rhodanese are aging-related proteins in human colonic epithelium, and injury of mitochondrial function and decline of antioxidant capability are important reasons for the aging of human colonic epithelium
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