HCSGD entry for TST
1. General information
| Official gene symbol | TST |
|---|---|
| Entrez ID | 7263 |
| Gene full name | thiosulfate sulfurtransferase (rhodanese) |
| Other gene symbols | RDS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000096 | Sulfur amino acid metabolic process | TAS | biological_process |
| GO:0000098 | Sulfur amino acid catabolic process | TAS | biological_process |
| GO:0004792 | Thiosulfate sulfurtransferase activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0008097 | 5S rRNA binding | IDA | molecular_function |
| GO:0009440 | Cyanate catabolic process | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0035928 | RRNA import into mitochondrion | IMP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051029 | RRNA transport | IDA | biological_process |
| GO:0070221 | Sulfide oxidation, using sulfide:quinone oxidoreductase | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0154632043 | 0.0806754303 | 0.3093562310 | 0.5371763218 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1660724939 |
| GSE13712_SHEAR | Down | -0.7608272828 |
| GSE13712_STATIC | Down | -0.2353124012 |
| GSE19018 | Up | 0.0709169889 |
| GSE19899_A1 | Up | 0.8158669827 |
| GSE19899_A2 | Up | 1.2578641800 |
| PubMed_21979375_A1 | Up | 1.6988683977 |
| PubMed_21979375_A2 | Up | 0.7514216969 |
| GSE35957 | Up | 1.1668576009 |
| GSE36640 | Up | 0.7788493415 |
| GSE54402 | Up | 0.3563287268 |
| GSE9593 | Down | -0.3711581738 |
| GSE43922 | Up | 0.4400843155 |
| GSE24585 | Up | 0.1931382130 |
| GSE37065 | Down | -0.4039019607 |
| GSE28863_A1 | Down | -1.0229865787 |
| GSE28863_A2 | Down | -0.1999135719 |
| GSE28863_A3 | Down | -1.1856895396 |
| GSE28863_A4 | Up | 0.1069881136 |
| GSE48662 | Down | -0.1938436846 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| S-Mercaptocysteine | DB02761 | EXPT01038 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-548b-3p | MIMAT0003254 | MIRT016237 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032127 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032251 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24470704 | This article describes relationships between telomere length and sleep parameters that included total sleep time (TST), wake after sleep onset (WASO), and self-reported sleep quality in a sample of adults with chronic illness |
| 24470704 | MEASUREMENTS AND RESULTS: TST and WASO were estimated with wrist actigraphy across 72 h; self-reported sleep quality was assessed with the Pittsburgh Sleep Quality Index |
| 20099848 | Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis |
| 20099848 | Rack1, EF-Tu and Rhodanese, three validated differential proteins, were further investigated for their role in the in vitro cell senescence |
| 20099848 | Taken together, our results suggest that Rack1, EF-Tu and Rhodanese are aging-related proteins in human colonic epithelium, and injury of mitochondrial function and decline of antioxidant capability are important reasons for the aging of human colonic epithelium |
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