HCSGD entry for TPH2

1. General information

Official gene symbolTPH2
Entrez ID121278
Gene full nametryptophan hydroxylase 2
Other gene symbolsADHD7 NTPH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004510Tryptophan 5-monooxygenase activityIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0007623Circadian rhythmIEAbiological_process
GO:0009072Aromatic amino acid family metabolic processIEAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0016597Amino acid bindingIEAmolecular_function
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042427Serotonin biosynthetic processIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043627Response to estrogenIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046219Indolalkylamine biosynthetic processTASbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0071285Cellular response to lithium ionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35396417310.94380740470.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0141011112
GSE13712_SHEARDown-0.0264770465
GSE13712_STATICDown-0.0089952463
GSE19018Up0.2141619871
GSE19899_A1Up0.2012768793
GSE19899_A2Up0.4040248068
PubMed_21979375_A1Down-0.0002214376
PubMed_21979375_A2Up0.3606997420
GSE35957Up0.1404609493
GSE36640Up0.1116166672
GSE54402Down-0.0839567284
GSE9593Up0.0204022633
GSE43922Up0.1617341723
GSE24585Up0.0377467483
GSE37065Down-0.0558121195
GSE28863_A1Down-0.0107956964
GSE28863_A2Up0.0628580219
GSE28863_A3Up0.1093783695
GSE28863_A4Down-0.0267615147
GSE48662Down-0.0415077552

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.