HCSGD entry for EDN3

1. General information

Official gene symbolEDN3
Entrez ID1908
Gene full nameendothelin 3
Other gene symbolsET-3 ET3 HSCR4 PPET3 WS4B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001755Neural crest cell migrationIEAbiological_process
GO:0002690Positive regulation of leukocyte chemotaxisIDAbiological_process
GO:0003100Regulation of systemic arterial blood pressure by endothelinIDAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005179Hormone activityIDAmolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayIDAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008015Blood circulationTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010460Positive regulation of heart rateIDAbiological_process
GO:0014824Artery smooth muscle contractionIDAbiological_process
GO:0014826Vein smooth muscle contractionIDAbiological_process
GO:0019229Regulation of vasoconstrictionIEAbiological_process
GO:0030072Peptide hormone secretionIDAbiological_process
GO:0030182Neuron differentiationIEAbiological_process
GO:0030318Melanocyte differentiationIEAbiological_process
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0042310VasoconstrictionIDAbiological_process
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0045840Positive regulation of mitosisIDAbiological_process
GO:0046887Positive regulation of hormone secretionIDAbiological_process
GO:0048016Inositol phosphate-mediated signalingIDAbiological_process
GO:0048070Regulation of developmental pigmentationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73720298620.86687343570.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0294123105
GSE13712_SHEARUp0.1698711663
GSE13712_STATICUp0.0448871534
GSE19018Down-0.0313320413
GSE19899_A1Down-0.0346871038
GSE19899_A2Up0.0819973080
PubMed_21979375_A1Up0.0916622582
PubMed_21979375_A2Down-0.1054916765
GSE35957Up0.0068457104
GSE36640Down-0.0761867554
GSE54402Up0.0399987917
GSE9593Up0.1014550692
GSE43922Up0.0587538906
GSE24585Down-0.0500480474
GSE37065Up0.0172333236
GSE28863_A1Down-0.0363440400
GSE28863_A2Down-0.0903215684
GSE28863_A3Up0.3443853588
GSE28863_A4Up0.0648025472
GSE48662Down-0.0206231016

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.