HCSGD entry for ARNT

1. General information

Official gene symbolARNT
Entrez ID405
Gene full namearyl hydrocarbon receptor nuclear translocator
Other gene symbolsHIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIDAbiological_process
GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationICbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA TASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003713Transcription coactivator activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0004874Aryl hydrocarbon receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIEA TASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010575Positive regulation vascular endothelial growth factor productionIDAbiological_process
GO:0017162Aryl hydrocarbon receptor bindingIPImolecular_function
GO:0030154Cell differentiationIEAbiological_process
GO:0030949Positive regulation of vascular endothelial growth factor receptor signaling pathwayICbiological_process
GO:0033235Positive regulation of protein sumoylationIEAbiological_process
GO:0042789MRNA transcription from RNA polymerase II promoterICbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043619Regulation of transcription from RNA polymerase II promoter in response to oxidative stressIDAbiological_process
GO:0045648Positive regulation of erythrocyte differentiationICbiological_process
GO:0045821Positive regulation of glycolysisICbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046886Positive regulation of hormone biosynthetic processIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19211972190.69213903730.85064464051.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2070855118
GSE13712_SHEARDown-0.1449044588
GSE13712_STATICDown-0.0713691011
GSE19018Up0.0828454607
GSE19899_A1Up0.0832237483
GSE19899_A2Up0.2338106339
PubMed_21979375_A1Up0.1396791450
PubMed_21979375_A2Up0.1662396529
GSE35957Up0.2279803648
GSE36640Up0.1590074102
GSE54402Down-0.2105940309
GSE9593Up0.0815995422
GSE43922Up0.1525275782
GSE24585Up0.4090618289
GSE37065Down-0.0104054359
GSE28863_A1Up0.5917753573
GSE28863_A2Up0.6627403826
GSE28863_A3Down-0.2444000448
GSE28863_A4Down-0.4480697437
GSE48662Down-0.0434450146

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-107MIMAT0000104MIRT004537qRT-PCR//Luciferase reporter assay//Western blot//Northern blot//Reporter assay;Western blotFunctional MTI20308559
hsa-miR-877-3pMIMAT0004950MIRT037117CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043236CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.